Skip to main content

Advertisement

Log in

Adenomyosis and accompanying gynecological pathologies

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The aim of the present study is to determine the potential risk factors for adenomyosis and to investigate its relationship with accompanying gynecological pathologies and clinical characteristics.

Materials and method

This study is a retrospective analysis of 945 patients who underwent hysterectomy between May 2005 and January 2013 at the Sifa University Medical Faculty Hospital, Clinic of Obstetrics and Gynecology. The study included 327 patients with adenomyosis and 618 patients without adenomyosis by histopathological examination of the uterus.

Results

There was a significant positive correlation between development of adenomyosis and presence of leiomyoma (p < 0.0001), history of previous abortion (p < 0.0001), history of previous pregnancy (p = 0.0002), and normal body mass index (p < 0.0001). However, no significant relationship existed between development of adenomyosis and smoking (p > 0.4300), normal delivery (p = 0.9600), cesarean delivery (p = 0.5705), endometrial hyperplasia (p = 0.1721), or ovarian endometriosis (p = 0.8595).

Conclusion

Women who are multiparous have leiomyoma, a previous history of abortion, and a normal body mass index are at increased risk for development of adenomyosis. Adenomyosis might be one cause of unexplained recurrent spontaneous abortion during pregnancy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Zaloudek C, Hendrickson MR (2002) Mesenchymal tumors of the uterus. In: Kurman RJ (ed) Blausteins’ pathology of the female genital tract, 5th edn. Springer, New York, pp 561–573

    Google Scholar 

  2. Rabinovici J, Inbar Y, Eylon SC, Schiff E, Hananel A, Freundlich D (2006) Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod 21(5):1255–1259

    Article  CAS  PubMed  Google Scholar 

  3. Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG (1997) Risk factors for adenomyosis. Hum Reprod 12(6):1275–1279

    Article  CAS  PubMed  Google Scholar 

  4. Bergholt T, Eriksen L, Berendt N, Jacobsen M, Hertz JB (2001) Prevalence and risk factors of adenomyosis at hysterectomy. Hum Reprod 16(11):2418–2421

    CAS  PubMed  Google Scholar 

  5. Karaer O, Oruç S, Koyuncu FM (2004) Aromatase inhibitors: possible future applications. Acta Obstet Gynecol Scand 83(8):699–706

    Article  PubMed  Google Scholar 

  6. Bulun SE (2009) Endometriosis. N Engl J Med 360(3):268–279

    Article  CAS  PubMed  Google Scholar 

  7. Parazzini F, Mais V, Cipriani S, Busacca M, Venturini P (2009) Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol 143(2):103–106

    Article  CAS  PubMed  Google Scholar 

  8. Bergeron C, Amant F, Ferenczy A (2006) Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:511–521

    Article  PubMed  Google Scholar 

  9. Ferenczy A (1998) Pathophysiology of adenomyosis. Hum Reprod Update 4(4):312–322

    Article  CAS  PubMed  Google Scholar 

  10. Kumar V, Cotran R, Robbins SL (1992) Basic Pathology, 5th edn. W.B. Saunders, Philadelphia, pp 615–616

    Google Scholar 

  11. Yeniel O, Cirpan T, Ulukus M, Ozbal A, Gundem G, Ozsener S, Zekioglu O, Yilmaz H (2007) Adenomyosis: prevalence, risk factors, symptoms and clinical findings. Clin Exp Obstet Gynecol. 34(3):163–167

    CAS  PubMed  Google Scholar 

  12. Saleh SS, Fram K (2012) Histopathology diagnosis in women who underwent a hysterectomy for a benign condition. Arch Gynecol Obstet 285(5):1339–1343

    Article  CAS  PubMed  Google Scholar 

  13. Levgur M, Abadi MA, Tucker A (2000) Adenomyosis: symptoms, histology, and pregnancy terminations. Obstet Gynecol 95(5):688–691

    Article  CAS  PubMed  Google Scholar 

  14. Templeman C, Marshall SF, Ursin G, Horn-Ross PL, Clarke CA, Allen M, Deapen D, Ziogas A, Reynolds P, Cress R, Anton-Culver H, West D, Ross RK, Bernstein L (2008) Adenomyosis and endometriosis in the California Teachers Study. Fertil Steril 90(2):415–424

    Article  PubMed Central  PubMed  Google Scholar 

  15. Martínez-Conejero JA, Morgan M, Montesinos M, Fortuño S, Meseguer M, Simón C, Horcajadas JA, Pellicer A (2011) Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril 96(4):943–950

    Article  PubMed  Google Scholar 

  16. Jaslow CR (2014) Uterine factors. Obstet Gynecol Clin North Am 41(1):57–86

    Article  PubMed  Google Scholar 

  17. Yan L, Ding L, Tang R, Chen ZJ (2014) Effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection outcomes in infertile women: a retrospective cohort study. Gynecol Obstet Invest 77(1):14–18

    Article  PubMed  Google Scholar 

  18. Shrestha A (2012) Risk factors for adenomyosis. J Nepal Health Res Counc. 10(22):229–233

    CAS  PubMed  Google Scholar 

  19. Vercellini P, Vigano P, Somigliana E, Daguati R, Abbiati A, Fedele I (2006) Adenomyosis: epidemiological factors. Best Pract Res Clin Obstet Gynaecol 20:465–477

    Article  PubMed  Google Scholar 

  20. Donnez J (2012) Endometriosis: enigmatic in the pathogenesis and controversial in its therapy. Fertil Steril 98(3):509–510

    Article  PubMed  Google Scholar 

  21. Novellas S, Chassang M, Delotte J, Toullalan O, Chevallier A, Bouaziz J, Chevallier P (2011) MRI characteristics of the uterine junctional zone: from normal to the diagnosis of adenomyosis. AJR Am J Roentgenol 196(5):1206–1213

    Article  PubMed  Google Scholar 

  22. Morelli M, Rocca ML, Venturella R, Mocciaro R, Zullo F (2013) Improvement in chronic pelvic pain after gonadotropin releasing hormone analogue (GnRH-a) administration in premenopausal women suffering from adenomyosis or endometriosis: a retrospective study. Gynecol Endocrinol 29(4):305–308

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

This notice is to document that there is no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mine Genc.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Genc, M., Genc, B. & Cengiz, H. Adenomyosis and accompanying gynecological pathologies. Arch Gynecol Obstet 291, 877–881 (2015). https://doi.org/10.1007/s00404-014-3498-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-014-3498-8

Keywords

Navigation