Abstract
Background
Retinol (ROH) is an essential micronutrient required for normal fetal development and an essential molecule for antioxidant processes.
Objective
To investigate the putative role of ROH as a marker of preeclampsia in early second trimester amniotic fluid (AF).
Materials and methods
Case–control study comparing the concentration of ROH and other antioxidants such as uric acid, vitamin E and malondialdehyde (MDA) in second trimester AF in patients that later developed preeclampsia with normal pregnancies.
Results
The concentration of ROH in amniotic fluids of women that later developed preeclampsia was significantly higher than those of uncomplicated pregnancies (66.72 µg/l (49.00–70.56) vs. 44.4 µg/l (31.9–51.17), p < 0.05). No statistical significant difference was found in uric acid, vitamin E and MDA concentration. In the multivariate logistic regression, concentrations of ROH in amniotic fluids directly correlate with the risk of developing preeclampsia (OR 1.13, IC 0.01–1.26, p < 0.05).
Conclusions
Second trimester AF ROH concentration was significantly higher in pregnancies that developed preeclampsia compared to normal pregnancies.
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Acknowledgments
The study results were presented at the 2nd National Congress of the FIOG (Federazione Italiana di Ostetricia e Ginecologia) on December 2009, Turin.
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There is no actual or potential conflict of interest.
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A. Fruscalzo, A. P. Londero contributed equally to the paper.
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Fruscalzo, A., Londero, A.P., Biasizzo, J. et al. Second trimester amniotic fluid retinol in patients developing preeclampsia. Arch Gynecol Obstet 291, 831–836 (2015). https://doi.org/10.1007/s00404-014-3477-0
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DOI: https://doi.org/10.1007/s00404-014-3477-0