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Antihypertensive therapy in preeclampsia is not modulated by VEGF polymorphisms

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Vascular endothelial growth factor (VEGF) is relevant for healthy pregnancy, and abnormalities in VEGF functions have been associated with hypertensive disorders of pregnancy. Our group recently demonstrated that VEGF genetic polymorphisms affect the susceptibility to preeclampsia (PE).

Objective

Therefore, in this study our aim is to examine whether VEGF polymorphisms affect the antihypertensive responses in women with PE.

Methods

We studied 113 white PE women who were stratified according to blood pressure levels after antihypertensive treatment (46 responsive, R group and 67 non-responsive, NR group). We then compared the frequencies of two VEGF genetic polymorphisms (C-2578A and G-634C) between R and NR groups.

Results

We found no significant differences in genotype or allele distributions between R and NR groups (P > 0.05). In addition, no difference was observed in overall distribution of haplotypes (P > 0.05).

Conclusion

Our data suggest that VEGF polymorphisms do not affect responsiveness to the antihypertensive therapy in PE.

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Acknowledgments

This work was funded by the ‘Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)’ and ‘Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)’.

Conflict of interest

All authors declare the absence of conflict.

Author information

Authors and Affiliations

  1. Departmento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil

    Valeria C. Sandrim

  2. Department of Pharmacology, Faculty of Medicinal Sciences, University of Campinas, State University of Campinas, Campinas, SP, Brazil

    Ana C. T. Palei

  3. Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil

    Nibia Eleuterio

  4. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil

    Jose E. Tanus-Santos

  5. Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil

    Ricardo C. Cavalli

Authors
  1. Valeria C. Sandrim
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  2. Ana C. T. Palei
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  3. Nibia Eleuterio
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  4. Jose E. Tanus-Santos
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  5. Ricardo C. Cavalli
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Correspondence to Valeria C. Sandrim.

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Sandrim, V.C., Palei, A.C.T., Eleuterio, N. et al. Antihypertensive therapy in preeclampsia is not modulated by VEGF polymorphisms. Arch Gynecol Obstet 291, 799–803 (2015). https://doi.org/10.1007/s00404-014-3475-2

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  • DOI: https://doi.org/10.1007/s00404-014-3475-2

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