Skip to main content
SpringerLink
Log in

The effect of inherited thrombophilia on second trimester combined aneuploidy screening test markers

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

An Erratum to this article was published on 11 October 2014

Abstract

Purpose

To determine whether inherited thrombophilia affects components of second trimester combined aneuploidy screening test.

Methods

A case–control study was performed between 1 December 2010 and 1 February 2012, at a tertiary referral hospital. Singleton pregnancies with inherited thrombophilia that underwent second trimester (16–19+6 week) combined aneuploidy screening test were included in the study. Maternal serum alfa fetoprotein, unconjugated estriol, human chorionic gonadotropin levels and multiple of median (MoM) levels were compared between the study group and controls.

Results

Within the study period, 18,943 women with singleton pregnancies had a combined second trimester aneuploidy screening test at our institution. Among these, 26 women met the criteria of thrombophilia. A control group that comprised 275 women with similar gestational age was generated, using a 1:1 ratio. Unconjugated estriol MoM levels were significantly lower in women with inherited thrombophilia (p = 0.02). But there was no statistically significant difference for unconjugated estriol levels, human chorionic gonadotropin, alfa fetoprotein and their MoM levels.

Conclusions

Our study suggest that in patients with hereditary thrombophilia a new correction factor should be used, when calculating unconjugated estriol MoM value, which is one of the markers of second trimester aneuploidy screening test.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Saller DN Jr, Canick JA (2008) Current methods of prenatal screening for Down syndrome and other fetal abnormalities. Clin Obstet Gynecol 51(1):24–36

    Article  PubMed  Google Scholar 

  2. Bogart M, Pandian MR, Jones OW (1987) Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities. Prenat Diagn 7(9):623–630

    Article  CAS  PubMed  Google Scholar 

  3. Canick JA, Knight GJ, Palomaki GE et al (1988) Low second trimester maternal serum unconjugated oestriol in pregnancies with Down’s syndrome. Br J Obstet Gynecol 95(4):330–333

    Article  CAS  Google Scholar 

  4. Wenstrom KD (2005) First trimester down syndrome screening: component analytes and timing for optimal performance. Semin Perinat 29(4):195–202

    Article  Google Scholar 

  5. Stella CL, Sibai B (2006) Thrombophilia and adverse maternal-perinatal outcome. Clin Obstet Gynecol 49(4):850–860

    Article  PubMed  Google Scholar 

  6. Vinatier D, Dufour P, Cosson M, Houpeau JL (2001) Antiphospholipid syndrome and recurrent miscarriages. Eur J Obstet Gynecol Reprod Biol 96(1):37–50

    Article  CAS  PubMed  Google Scholar 

  7. Brenner B, Sarig G, Wainer Z et al (1999) Thrombophilic polymorphisms are common in women with fetal loss without apparent cause. Thromb Hemostas 82(1):6–9

    CAS  Google Scholar 

  8. Brochet C, Morin N, Coudert M et al (2009) Impact of antiphospholipid biology in maternal Down syndrome screening. Prenat Diagn 29(5):481–488

    Article  PubMed  Google Scholar 

  9. Irwin JC, Suen LF, Martina NA et al (1999) Role of the IGF system in trophoblast invasion and pre-eclampsia. Hum Reprod 14(2):90–96

    Article  CAS  PubMed  Google Scholar 

  10. Spencer K, Yu CK, Cowans NJ et al (2005) Prediction of pregnancy complications by first-trimester maternal serum PAPP-A and free beta-hCG and with second-trimester uterine artery Doppler. Prenat Diagn 25(10):949–953

    Article  CAS  PubMed  Google Scholar 

  11. Derbent AU, Yanik FF, Inegöl Gümüş I et al (2012) Impact of inherited thrombophilias on first and second trimester maternal serum markers for aneuploidy. J Matern Fetal Neonatal Med 25(11):2177–2181

    Article  CAS  PubMed  Google Scholar 

  12. Gagnon A, Wilson RD, Audibert F et al (2008) Obstetrical complications associated with abnormal maternal serum markers analytes. J Obstet Gynaecol Can 30(10):918–949

    PubMed  Google Scholar 

  13. Frank M, Maymon R, Wiener Y et al (2013) The effect of hereditary versus acquired thrombophilia on triple test Down’s syndrome screening. Prenat Diagn 33(2):191–195

    Article  CAS  PubMed  Google Scholar 

  14. Brochet C, Morin N, Coudert M et al (2009) Impact of antiphospholipid biology in maternal Down syndrome screening. Prenat Diagn 29(5):481–488

    Article  PubMed  Google Scholar 

  15. Yaron Y, Cherry M, Kramer RL et al (1999) Second-trimester maternal serum marker screening: maternal serum alpha-fetoprotein, beta-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome. Am J Obstet Gynecol 181(4):968–974

    Article  CAS  PubMed  Google Scholar 

  16. Shenhav S, Gemer O, Sassoon E et al (2002) Mid-trimester triple test levels in early and late onset severe pre-eclampsia. Prenat Diagn 22(7):579–582

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors have no conflict of interest with this study.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Altindag, Ankara, Turkey

    Muzaffer Seyhan Cıkman, Kerem Doga Seckin, Mehmet Fatih Karslı, Eralp Baser & Mahmut Nedim Cicek

  2. Department of Internal Medicine, Hacettepe University Hospital, Ankara, Turkey

    Duygu Ilke Cıkman

Authors
  1. Muzaffer Seyhan Cıkman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kerem Doga Seckin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mehmet Fatih Karslı
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eralp Baser
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Duygu Ilke Cıkman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mahmut Nedim Cicek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kerem Doga Seckin.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cıkman, M.S., Seckin, K.D., Karslı, M.F. et al. The effect of inherited thrombophilia on second trimester combined aneuploidy screening test markers. Arch Gynecol Obstet 291, 787–790 (2015). https://doi.org/10.1007/s00404-014-3468-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-014-3468-1

Keywords

Search

Navigation