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Comparison of maternal and umbilical cord blood soluble lectin-like oxidized low-density lipoprotein receptor 1 levels in early- and late-onset preeclampsia

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
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Abstract

Background

The main purpose of this study was to determine the maternal and umbilical cord blood oxidized LDL (oxLDL) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in early- and late-onset preeclampsia (PE).

Materials and methods

A case–control study was conducted in pregnant women with early-onset (before 34 weeks’ gestation n = 19) and late-onset (after 34 weeks’ gestation n = 22) PE compared to healthy normotensive pregnant controls (n = 44). Groups were compared for the maternal and umbilical cord plasma oxLDL and serum sLOX-1 levels.

Results

The mean maternal and umbilical cord serum sLOX-1 and plasma oxLDL levels were significantly increased in early- and late-onset PE compared to controls (p < 0.001). When early- and late-onset PE women were compared with serum sLOX-1 levels, the increase was more pronounced in early PE (p < 0.001). However, same comparison is not statistically significant in cord blood for oxLDL where as it is significantly higher in maternal blood for oxLDL in early-onset PE group. Maternal and cord blood oxLDL and sLOX-1 levels are positively correlated with each other; however, they are negatively correlated with fetal weight and gestational age.

Conclusions

According to our results, maternal and umbilical cord blood levels of oxLDL and sLOX-1 were higher in preeclamptic pregnant. Thus, for the first time it has been shown that oxLDL and sLOX-1 levels were higher in fetal circulation as well as plasma of preeclamptic pregnant. However, sLOX-1 levels seem to be more implying than oxLDL for the differentiation of early and late preeclampsia.

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Acknowledgments

This work was supported by The Research Fund of Istanbul University (Project Number: BYP-21176).

Conflict of interest

The authors declare that they have no conflicts of interest related to the publication of this manuscript.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    A. Tuten, M. Oncul & S. Acıkgoz

  2. Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, 34303, Cerrahpaşa-Istanbul, Turkey

    H. Erman, R. Gelisgen & H. Uzun

  3. School of Health, Kırklareli University, Kırklareli, Turkey

    G. G. Korkmaz

  4. Department of Physiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey

    G. Simsek

  5. Department of Biochemistry, Yildiz Technical University, Istanbul, Turkey

    V. Sozer

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  1. A. Tuten
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  4. M. Oncul
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  9. H. Uzun
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Correspondence to H. Uzun.

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Tuten, A., Erman, H., Korkmaz, G.G. et al. Comparison of maternal and umbilical cord blood soluble lectin-like oxidized low-density lipoprotein receptor 1 levels in early- and late-onset preeclampsia. Arch Gynecol Obstet 290, 1007–1013 (2014). https://doi.org/10.1007/s00404-014-3294-5

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  • DOI: https://doi.org/10.1007/s00404-014-3294-5

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