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Benign schwannoma in supraclavicular region: a false-positive lymph node recurrence of breast cancer suspected by PET scan

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Abstract

Introduction

Positron emission tomography (PET) is the most accurate imaging modalities to detect malignancies. And it helps to take decisions regarding diagnosis, staging, recurrence, and therapeutical management.

Case presentation

We report a case of a suspected supraclavicular lymph node relapse, diagnosed by PET-CT in a breast cancer patient. The lymph node was surgically removed in outpatient with local anesthesia. Histological findings diagnosed a benign Schwannoma. In this patient PET-CT failed to distinguish benign tumors from metastatic supraclavicular lymph nodes.

Conclusion

This case confirms the need to investigate histologically suspected supraclavicular lesions, during breast cancer follow up.

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References

  1. Xie L, Higginson DS, Marks LB (2011) Elective regional nodal irradiation in patients with early-stage breast cancer. Semin Radiat Oncol 21(1):66–78 (Review)

    Article  PubMed  Google Scholar 

  2. Fowble B, Solin LJ, Schultz DJ, Goodman RL (1989) Frequency, sites of relapse, and out come of regional node failures following conservative surgery and radiation for early breast cancer. Int J Radiat Oncol Biol Phys 17(4):703–710

    Article  CAS  PubMed  Google Scholar 

  3. Reddy SG, Kiel KD (2007) Supraclavicular nodal failure in patients with one to three positive axillary lymph nodes treated with breast conserving surgery and breast irradiation, without supraclavicular node radiation. Breast J 13(1):12–18

    Article  PubMed  Google Scholar 

  4. Pedersen AN, Møller S, Steffensen KD, Haahr V, Jensen M, Kempel MM et al (2011) Supraclavicular recurrence after early breast cancer: a curable condition? Breast Cancer Res Treat 125(3):815–822

    Article  PubMed  Google Scholar 

  5. Sangen MJ, Coebergh JW, Roumen RM et al (2003) Detection, treatment, and outcome of isolated supraclavicular recurrence in 42 patients with invasive breast carcinoma. Cancer 98(1):11–17

    Article  PubMed  Google Scholar 

  6. Brito RA, Valero V, Buzdar AU et al (2001) Long-term results of combined-modality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases: the University of Texas M.D. Anderson cancer center experience. J Clin Oncol 19(3):628–633

    CAS  PubMed  Google Scholar 

  7. Pergolizzi S, Adamo V, Russi E et al (2006) Prospective multicenter study of combined treatment with chemotherapy and radiotherapy in breast cancer women with the rare clinical scenario of ipsilateral supraclavicular node recurrence without distant metastases. Int J Radiat Oncol Biol Phys 65(1):25–32 (Epub 2006 Jan 30)

    Article  PubMed  Google Scholar 

  8. Abraham R, Nagy T, Goss PE, Crump M (2000) High dose chemotherapy and autologous blood stem cell support in women with breast carcinoma and isolated supraclavicular lymph node metastases. Cancer 88(4):790–795

    Article  CAS  PubMed  Google Scholar 

  9. Pennant M, Takwoingi Y, Pennant L, Davenport C, Fry-Smith A et al (2010) A systematic review of positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) for the diagnosis of breast cancer recurrence. Health Technol Assess 14(50):1–103

    CAS  Google Scholar 

  10. Pons F, Duch J, Fuster D (2009) Breast cancer therapy: the role of PET-CT in decision making. Q J Nucl Med Mol Imaging 53(2):210–223

    CAS  PubMed  Google Scholar 

  11. Ueda S, Tsuda H, Asakawa H, Omata J, Fukatsu K, Kondo N et al (2008) Utility of 18F-fluorodeoxyglucose emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in combination with ultrasonography for axillary staging in primary breast cancer. BMC Cancer 9(8):165

    Article  Google Scholar 

  12. Fujiuchi N, Saeki T, Takeuchi H, Sano H, Takahashi T, Matsuura K et al (2011) A false positive for metastatic lymph nodes in the axillary region of a breast cancer patient following mastectomy. Breast Cancer 18(2):141–144

    Google Scholar 

  13. Goh BK, Tan YM, Chung YF, Chow PK, Ooi LL, Wong WK (2006) Retroperitoneal schwannoma. Am J Surg 192:14–18

    Article  PubMed  Google Scholar 

  14. Sharma BS, Banarjee AK, Kak VK (1989) Malignant schwannoma of brachial plexus presenting as spinal cord compression. Neurochirurgia (Stuttq) 32(6):189–191

    CAS  Google Scholar 

  15. Inoue M, Kawano T, Matsumura H, Mori K, Yoshida T (1983) Solitary benign schwannoma of the brachial plexus. Surg Neurol 20(2):103–108

    Article  CAS  Google Scholar 

  16. Richardson RR, Siqueira EB, Oi S, Nunez C (1979) Neurogenic Tumors of the brachial plexus: report of two cases. Neurosurgery 4(1):66–70

    Article  CAS  PubMed  Google Scholar 

  17. Sperlongano P, Parmeggiani D, Pisaniello D, Sordelli I, Biondi P, Apicella A et al (2007) Surgical treatment with ligasure precise of schwannoma of brachial plexus: a case report. G Chir 28(3):99–102

    CAS  PubMed  Google Scholar 

  18. Leal Filho MB, Aquiar Ade A, De Almeida BR, Dantas kDa S, Vieira MA, De Morais RK et al (2004) Schwannoma of brachial plexus: report of two cases. Arq Neuropsiquiatr 62(1):162–166

    Article  PubMed  Google Scholar 

  19. Ahn JY, Kwon SO, Shin MS, Shim JY, Kim OJ (2002) A case of multiple schwannomas of the trigeminal nerves, acoustic nerves, lower cranial nerves, brachial plexuses and spinal canal: shwannomatosis or neurofibromatosis? Yonsei Med J 43(1):109–113

    PubMed  Google Scholar 

  20. Miyawaki T, Nakamura A, Hayashi H, Kurihara K (1999) Macrocystic schwannoma in the seventh cervical nerve. Plast Reconstr Surg 104(3):789–792

    Article  CAS  PubMed  Google Scholar 

  21. Colreavy MP, Lacy PD, Hughes J, Bouchier-Hayes D, Brennan P, O’Dwyer AJ et al (2000) Head and neck schwannomas—a 10 year review. J Laryngol Otol 114(2):119–124

    Article  CAS  PubMed  Google Scholar 

  22. Chen SC, Chang HK, Lin YC et al (2006) Prognosis of breast cancer after supraclavicular lymph node metastasis: not a distant metastasis. Ann Surg Oncol 13:1457–1465

    Article  PubMed  Google Scholar 

  23. Van der Sangen MJ, Coebergh JW, Roumen RM et al (2003) Detection, treatment, and outcome of isolated supraclavicular recurrence in 42 patients with invasive breast carcinoma. Cancer 98:1117

    Google Scholar 

  24. Beaulieu S, Rubin B, Djang D, Conrad E, Turcotte E, Eary JF (2004) Positron emission tomography of schwannomas: emphasizing its potential in preoperative planning. Am J Roentgenol 182(4):971–974

    Article  Google Scholar 

  25. Ahmed AR, Watanabe H, Aoki J, Shinozaki T, Takagishi K (2001) Schwannoma of the extremities: the role of PET in preoperative planning. Eur J Nucl Med 28(10):1541–1551

    Article  CAS  PubMed  Google Scholar 

  26. Woodruff JM, Godwin TA, Erlandson RA, Susin M, Martini N (1981) Cellular schwannoma: a variety of schwannoma sometimes mistaken for a malignant tumor. Am J Surg Pathol 5(8):733–744

    Article  CAS  PubMed  Google Scholar 

  27. Nakamura M, Akao S (2000) Neurilemmoma arising in the brachial plexus in association with breast cancer: report of case. Surg Today 30(11):1012–1051

    Article  CAS  PubMed  Google Scholar 

  28. Chen F, Miyahara R, Matsunaga Y, Koyama T (2008) Schwannoma of the brachial plexus presenting as an enlarging cystic mass: report of a case. Ann Thorac Cardiovasc Surg 14:311–331

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, University of Rome “Sapienza”, V.le Del Policlinico, 155, 00161, Rome, Italy

    Giorgia Perniola, Federica Tomao, Margherita Fischetti, Stephanie Lio & Pierluigi Benedetti Panici

  2. Department of Anatomo-pathology, University of Rome “Sapienza”, Rome, Italy

    Irene Pecorella

Authors
  1. Giorgia Perniola
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  2. Federica Tomao
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  3. Margherita Fischetti
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  4. Stephanie Lio
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  5. Irene Pecorella
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  6. Pierluigi Benedetti Panici
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Corresponding author

Correspondence to Margherita Fischetti.

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Perniola, G., Tomao, F., Fischetti, M. et al. Benign schwannoma in supraclavicular region: a false-positive lymph node recurrence of breast cancer suspected by PET scan. Arch Gynecol Obstet 290, 583–586 (2014). https://doi.org/10.1007/s00404-014-3241-5

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  • DOI: https://doi.org/10.1007/s00404-014-3241-5

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