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Lymph node metastasis in patients with epithelial ovarian cancer macroscopically confined to the ovary: review of a single-institution experience

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

To evaluate the patterns of lymphatic spread in epithelial ovarian cancer (EOC) macroscopically confined to the ovary and to determine risk factors for lymph node metastasis.

Materials and methods

All patients with clinically apparent stage IA/B/C EOCs who underwent staging surgery between January 2003 and February 2013 were retrospectively identified.

Results

Two hundred and thirty-six (n = 236) consecutive patients were operated for primary epithelial ovarian carcinoma. Sixty-two of these patients (26.2 %) who underwent a comprehensive staging procedure including pelvic and paraaortic lymphadenectomy were diagnosed with tumors confined to one or two ovaries (stage IA/B/C). Of these 62 patients, 17 (27.4 %) had upstaged disease and 8 (12.9 %) had lymph node metastasis. Tumor histology was serous in 25 patients (40.3 %), mucinous in 23 patients (37 %), endometrioid in 9 patients (14.5 %), and clear cell in 5 patients (8 %). Positive lymph node status was found in 20 % (5/25) of those with serous histology while this rate was only 8.1 % (3/37) in those with non-serous disease. Although the presence of ascites was not associated with an increased risk of lymph node involvement (p = 0.24), positive peritoneal cytology (p = 0.001) and grade 3 disease (p = 0.001) were significant predictors of lymph node involvement.

Conclusion

All patients diagnosed with EOC macroscopically confined to the ovary should be considered for comprehensive staging surgery including pelvic and paraaortic lymphadenectomy.

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Conflict of interest

We declare that we have no conflicts of interest.

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Authors and Affiliations

  1. Oncology Unit, Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey

    Volkan Ulker, Ceyhun Numanoglu & Ozgur Akbayır

  2. Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey

    Oguzhan Kuru & Ibrahim Polat

  3. Department of Pathology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey

    Mehmet Uhri

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  1. Volkan Ulker
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  2. Oguzhan Kuru
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  3. Ceyhun Numanoglu
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  4. Ozgur Akbayır
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  5. Ibrahim Polat
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  6. Mehmet Uhri
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Correspondence to Oguzhan Kuru.

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Ulker, V., Kuru, O., Numanoglu, C. et al. Lymph node metastasis in patients with epithelial ovarian cancer macroscopically confined to the ovary: review of a single-institution experience. Arch Gynecol Obstet 289, 1087–1092 (2014). https://doi.org/10.1007/s00404-013-3078-3

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  • DOI: https://doi.org/10.1007/s00404-013-3078-3

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