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Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized double-blind placebo-controlled trial

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To determine whether administration of vitamin D affects the success rates of intra uterine insemination (IUI) in infertile polycystic ovarian syndrome (PCOS) women and their endometrial thickness.

Methods

This randomized, double-blind, placebo-controlled trial was conducted in an infertility clinic of Women’s Hospital, and 110 infertile PCOS patients undergoing IUI were randomly divided to receive vitamin D or placebo. Endometrial thickness, IUI results, number of dominant follicles, duration of IUI cycle, and dose of HMG used in IUI were determined.

Results

The endometrial thickness was significantly different in the group treated with vitamin D versus the placebo group (p = 0.003). There was no statistical difference in pregnancy out come between the two groups (RR = 1.167, CI 95 % 0.70–1.93). No statistical difference was found in number of dominant follicles (p = 0.96), duration of IUI cycles (p = 0.70) and dose of HMG used for IUI (p = 0.95).

Conclusions

It seems that administration of vitamin D induces endometrial proliferation in PCOS women during IUI cycle.

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Acknowledgments

The study was supported by a grant from Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences. Also the study was performed in menopause clinic of Tehran women general hospital of Tehran University of medical sciences.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mojgan Asadi

  2. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mojgan Asadi

  3. Tehran University of Medical Science, Tehran, Iran

    Nasim Matin, Mitra Frootan, Jaleh Mohamadpour & Fatemeh Davari Tanha

  4. Department of Public Health, Alborz University of Medical Sciences, Karaj, Iran

    Mostafa Qorbani

  5. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran

    Mostafa Qorbani

  6. Women’s Hospital, North Nejatollahi Ave-Poule Karim Khan Zand, Tehran, Iran

    Fatemeh Davari Tanha

Authors
  1. Mojgan Asadi
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  2. Nasim Matin
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  3. Mitra Frootan
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  4. Jaleh Mohamadpour
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  5. Mostafa Qorbani
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  6. Fatemeh Davari Tanha
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Corresponding author

Correspondence to Fatemeh Davari Tanha.

Additional information

The study was recorded in Iranian Registry of Clinical Trials (IRCT201104216246N1).

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Asadi, M., Matin, N., Frootan, M. et al. Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized double-blind placebo-controlled trial. Arch Gynecol Obstet 289, 865–870 (2014). https://doi.org/10.1007/s00404-013-3055-x

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  • DOI: https://doi.org/10.1007/s00404-013-3055-x

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