Archives of Gynecology and Obstetrics

, Volume 289, Issue 3, pp 601–608 | Cite as

Triple therapy with Lactobacilli acidophili, estriol plus pelvic floor rehabilitation for symptoms of urogenital aging in postmenopausal women

  • Giampiero CapobiancoEmail author
  • Jean Marie Wenger
  • Giovanni Battista Meloni
  • Margherita Dessole
  • Pier Luigi Cherchi
  • Salvatore Dessole
General Gynecology



To assess the effects of the combination of pelvic floor rehabilitation, intravaginal estriol and Lactobacillus acidophli administration on stress urinary incontinence (SUI), urogenital atrophy and recurrent urinary tract infections in postmenopausal women.


136 postmenopausal women with urogenital aging symptoms were enrolled in this prospective randomized study. Patients: randomly divided into two groups and each group consisted of 68 women. Interventions: Subjects in the triple therapy (group I) received 1 intravaginal ovule containing 30 mcg estriol and Lactobacilli acidophili (50 mg lyophilisate containing at least 100 million live bacteria) such as once daily for 2 weeks and then two ovules once weekly for a total of 6 months as maintenance therapy plus pelvic floor rehabilitation. Subjects in the group II received one intravaginal estriol ovule (1 mg) plus pelvic floor rehabilitation in a similar regimen. Mean outcome measures: We evaluated urogenital symptomatology, urine cultures, colposcopic findings, urethral cytologic findings, urethral pressure profiles and urethrocystometry before, as well as after 6 months of treatment.


After therapy, the symptoms and signs of urogenital atrophy significantly improved in both groups. 45/59 (76.27 %) of the group I and 26/63 (41.27 %) of the group II referred a subjective improvement of their incontinence. In the patients treated by triple therapy with lactobacilli, estriol plus pelvic floor rehabilitation, we observed significant improvements of colposcopic findings, and there were statistically significant increases in mean maximum urethral pressure, in mean urethral closure pressure, as well as in the abdominal pressure transmission ratio to the proximal urethra.


Our results showed that triple therapy with L. acidophili, estriol plus pelvic floor rehabilitation was effective and should be considered as first-line treatment for symptoms of urogenital aging in postmenopausal women.


Pelvic floor rehabilitation Postmenopausal women Recurrent urinary tract infections Urogenital atrophy Urinary incontinence Lactobacillus acidophili Vaginal estriol 


Conflict of interest

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Giampiero Capobianco
    • 1
    Email author
  • Jean Marie Wenger
    • 2
  • Giovanni Battista Meloni
    • 3
  • Margherita Dessole
    • 1
  • Pier Luigi Cherchi
    • 1
  • Salvatore Dessole
    • 1
  1. 1.Department of Surgical, Microsurgical and Medical Sciences Gynecologic and Obstetric ClinicUniversity of SassariSassariItaly
  2. 2.Gynecologic and Obstetric ClinicUniversity of GinevraGinevraSwitzerland
  3. 3.Department of Surgical, Microsurgical and Medical Sciences, Institute of RadiologyUniversity of SassariSassariItaly

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