Abstract
Purpose
This study investigated whether there is a correlation between levels of 25OH-D in the follicular fluid and the serum of infertile women and the results of IVF and rates of pregnancy. The association between the levels of 25OH-D in the follicular fluid and the vitamin D repletion status was also assessed.
Methods
Two hundred and twenty-one infertile women participated in an IVF cycle from 2010 to 2011 in a prospective observational study. Serum and follicular fluid were collected for vitamin D analysis. Deficient, insufficient, and sufficient levels of vitamin D were defined as 10, 10–29, and 30–100 ng/ml, respectively. IVF cycle parameters and clinical pregnancy rates were also compared with the vitamin D level.
Results
The levels of vitamin D deficiency, insufficiency, and sufficiency were 22.6, 70.1, and 7.2 %, respectively. The fertilization rates associated with these three levels of vitamin D were 43.17, 53.37, and 58.77 %, respectively, (P = 0.054), and the implantation rates were 17.33, 15.26, and 18.75 %, respectively, (P = 0.579). No significant correlation was seen between the pregnancy rate and the serum vitamin D level (P = 0.094) or the follicular vitamin D level (P = 0.170). The serum and follicular fluid vitamin D levels showed a significant correlation (P = 0.000).
Conclusion
Although vitamin D is an important hormone in the human body, no correlation was found between the serum and follicular vitamin D level and the pregnancy rate in the IVF cycle.
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Acknowledgments
The researchers wish to thank all the staff of Yazd Research and Clinical Center for Infertility for their invaluable and kind assistance in this research project. This study was supported by Shahid Sadoughi University of Medical Sciences.
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The authors certify that no actual or potential conflict of interest in relation to this article exists.
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Firouzabadi, R.D., Rahmani, E., Rahsepar, M. et al. Value of follicular fluid vitamin D in predicting the pregnancy rate in an IVF program. Arch Gynecol Obstet 289, 201–206 (2014). https://doi.org/10.1007/s00404-013-2959-9
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DOI: https://doi.org/10.1007/s00404-013-2959-9