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Elevated diastolic blood pressure in insulin-resistant polycystic ovarian syndrome patients

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The purpose of this study was to further understand interrelationships between insulin resistance in PCOS and elevated diastolic blood pressure.

Design

A prospective case control study.

Participants

Fifty normal women and 43 PCOS patients, 16 of them with insulin resistance.

Setting

Academic Institution.

Interventions

Clinical, anthropometric and ultrasonographic features of PCOS were assessed, as were blood levels for luteinizing hormone, follicle-stimulating hormone, androstenedione, DHEAS, and basal insulin. A lipid profile and an oral glucose tolerance test (OGTT) were also performed.

Main outcome measures

To demonstrate the effect of insulin resistance on blood pressure in patients with PCOS.

Results

Patients with PCOS and those with PCOS plus insulin resistance (IR) had significantly elevated levels of plasma androgen but only those with IR showed greater body mass index and waist: hip ratios than PCOS or control. PCOS plus IR differed significantly in their response to OGTT when compared to PCOS or control. Alterations in lipid profile were shown to be atherogenic. Patients with PCOS plus IR demonstrated a significant elevation of diastolic blood pressure when compared to PCOS alone or controls.

Conclusions

We hypothesize that hyperlipidemia and IR may be involved in the pathophysiologic features of the elevated diastolic blood pressure in PCOS patients.

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Authors and Affiliations

  1. Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

    Angélica Maria Holanda Pascoal da Silva, Ana Carolina Rodrigues de Andrade, Bruno Hállan Meneses Dias, Vietla Satianarayana Rao & Francisco das Chagas Medeiros

  2. University of Fortaleza, Fortaleza, Ceará, Brazil

    Maria Angelina da Silva Medeiros

  3. Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

    Vietla Satianarayana Rao

  4. Department of Maternal and Child Health, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

    Francisco das Chagas Medeiros

  5. Maternidade Escola Assis Chateaubriand, Rua Coronel Nunes de Melo, S/N-Rodolfo Teófilo, Fortaleza, CE, 60430-270, Brazil

    Francisco das Chagas Medeiros

Authors
  1. Angélica Maria Holanda Pascoal da Silva
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  2. Ana Carolina Rodrigues de Andrade
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  3. Bruno Hállan Meneses Dias
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  4. Maria Angelina da Silva Medeiros
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  5. Vietla Satianarayana Rao
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  6. Francisco das Chagas Medeiros
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Corresponding author

Correspondence to Francisco das Chagas Medeiros.

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da Silva, A.M.H.P., de Andrade, A.C.R., Dias, B.H.M. et al. Elevated diastolic blood pressure in insulin-resistant polycystic ovarian syndrome patients. Arch Gynecol Obstet 289, 119–122 (2014). https://doi.org/10.1007/s00404-013-2953-2

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  • DOI: https://doi.org/10.1007/s00404-013-2953-2

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