Archives of Gynecology and Obstetrics

, Volume 288, Issue 5, pp 1045–1049 | Cite as

Copeptin concentrations are not elevated in gestational diabetes mellitus

  • Mahmut Oncul
  • Abdullah Tuten
  • Mine KucurEmail author
  • Metehan Imamoglu
  • Ozlem Balcı Ekmekci
  • Abdullah Serdar Acıkgoz
  • Rıza Madazlı
Maternal-Fetal Medicine



To investigate copeptin levels in women with GDM and women with uncomplicated pregnancies.


This case–control study was conducted on 45 women with GDM and 40 women with uncomplicated pregnancies. The maternal serum levels of copeptin were measured with enzyme-linked immunosorbent assay.


Copeptin levels were not different among groups (0.93 ± 0.75 vs. 1.15 ± 0.93 ng/ml, p: 0.24). HOMA-IR and insulin levels were significantly higher in woman with GDM when compared with control group (2.90 ± 1.88 vs. 1.91 ± 0.50, p: 0.002; 11.74 ± 6.43 vs. 8.52 ± 2.28, p: 0.004, respectively). The copeptin concentrations were significantly correlated with insulin levels and HOMA-IR values (r = 0.329 p = 0.002, r = 0.289 p = 0.007, respectively).


The present study shows that serum copeptin concentrations did not differ in woman with GDM and non-GDM patients. However, we found a significant correlation between copeptin and HOMA-IR. Future studies are needed with larger populations in gestational diabetic patients on copeptin secretion, metabolism and action.


Gestational diabetes mellitus Copeptin Insulin resistance 


Conflict of interest

Authors declare no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Mahmut Oncul
    • 1
  • Abdullah Tuten
    • 1
  • Mine Kucur
    • 2
    Email author
  • Metehan Imamoglu
    • 1
  • Ozlem Balcı Ekmekci
    • 2
  • Abdullah Serdar Acıkgoz
    • 1
  • Rıza Madazlı
    • 1
  1. 1.Department of Obstetrics and GynecologyIstanbul University, Cerrahpasa Medical FacultyIstanbulTurkey
  2. 2.Department of Medical BiochemistryIstanbul University, Cerrahpasa Medical FacultyIstanbulTurkey

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