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The combined therapy myo-inositol plus d-chiro-inositol, rather than d-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial

Archives of Gynecology and Obstetrics volume 288, pages 1405–1411 (2013)Cite this article

Abstract

Purpose

The present study aims to investigate the effects of the combined therapy myo-inositol (MI) plus d-chiro-inositol (DCI) or d-chiro-inositol treatment in oocyte quality.

Methods

Polycystic ovary syndrome (PCOS) women undergoing IVF-ET were treated with myo-inositol combined with d-chiro-inositol in the physiological ratio (1.1 g myo-inositol plus 27.6 mg of d-chiro-inositol; INOFOLIC® combi Lo.Li.pharma) or d-chiro-inositol alone (500 mg; Interquim, s.a., Barcelona, Spain) to evaluate the umber of morphological mature oocytes, total International Units (IU) of recombinant FSH administered and the number of grade 1 embryos.

Results

The data clearly showed that only the combined therapy was able to improve oocyte and embryo quality, as well as pregnancy rates, in PCOS women undergoing IVF-ET.

Conclusion

The present paper further supports the hypothesis that MI plays a crucial role in the ovary in PCOS women. In particular, due to the physiological role played by MI and DCI, the combined therapy should represent a better choice.

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Authors and Affiliations

  1. Department of Psychology, Section of Neuroscience, University of Rome “Sapienza”, Via dei Marsi 78, 00185, Rome, Italy

    Sandra Colazingari & Arturo Bevilacqua

  2. Centro di Ricerca in Neurobiologia Daniel Bovet (CRiN), Rome, Italy

    Sandra Colazingari & Arturo Bevilacqua

  3. Leda Fertility Center, Via del Giordano 34, 00144, Rome, Italy

    Mariangela Treglia & Robert Najjar

Authors
  1. Sandra Colazingari
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  2. Mariangela Treglia
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  3. Robert Najjar
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  4. Arturo Bevilacqua
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Correspondence to Arturo Bevilacqua.

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Colazingari, S., Treglia, M., Najjar, R. et al. The combined therapy myo-inositol plus d-chiro-inositol, rather than d-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial. Arch Gynecol Obstet 288, 1405–1411 (2013). https://doi.org/10.1007/s00404-013-2855-3

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  • DOI: https://doi.org/10.1007/s00404-013-2855-3

Keywords

  • Myo-inositol
  • d-chiro-inositol
  • Oocyte quality
  • IVF
  • Embryo quality