Archives of Gynecology and Obstetrics

, Volume 288, Issue 6, pp 1405–1411 | Cite as

The combined therapy myo-inositol plus d-chiro-inositol, rather than d-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial

  • Sandra Colazingari
  • Mariangela Treglia
  • Robert Najjar
  • Arturo Bevilacqua
Reproductive Medicine



The present study aims to investigate the effects of the combined therapy myo-inositol (MI) plus d-chiro-inositol (DCI) or d-chiro-inositol treatment in oocyte quality.


Polycystic ovary syndrome (PCOS) women undergoing IVF-ET were treated with myo-inositol combined with d-chiro-inositol in the physiological ratio (1.1 g myo-inositol plus 27.6 mg of d-chiro-inositol; INOFOLIC® combi Lo.Li.pharma) or d-chiro-inositol alone (500 mg; Interquim, s.a., Barcelona, Spain) to evaluate the umber of morphological mature oocytes, total International Units (IU) of recombinant FSH administered and the number of grade 1 embryos.


The data clearly showed that only the combined therapy was able to improve oocyte and embryo quality, as well as pregnancy rates, in PCOS women undergoing IVF-ET.


The present paper further supports the hypothesis that MI plays a crucial role in the ovary in PCOS women. In particular, due to the physiological role played by MI and DCI, the combined therapy should represent a better choice.


Myo-inositol d-chiro-inositol Oocyte quality IVF Embryo quality 


Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Sandra Colazingari
    • 1
    • 2
  • Mariangela Treglia
    • 3
  • Robert Najjar
    • 3
  • Arturo Bevilacqua
    • 1
    • 2
  1. 1.Department of Psychology, Section of NeuroscienceUniversity of Rome “Sapienza”RomeItaly
  2. 2.Centro di Ricerca in Neurobiologia Daniel Bovet (CRiN)RomeItaly
  3. 3.Leda Fertility CenterRomeItaly

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