Are ABO and Rh blood groups new genetic risk factors for endometriosis?
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Endometriosis is a complex gynecologic disorder with a particular genetic roots and 5–7 % recurrent risk for first-degree relatives of patients and occurs in about 5–10 % of women in reproductive age and up to 50 % of women with infertility. Several studies have revealed that endometriosis arises from an interaction between genetics and environmental factors [1, 2]. Up to now, association between different malignancies with ABO and Rh antigens (which are located on the membrane of human cells especially blood cells) have documented in the literature while explanation for these associations is still unknown although an important hypothesis is that these antigens facilitate cellular mobility in tumors .
ABO and Rh genes are located on 9q34 and 1p36 chromosome, respectively, and have been assumed as genetic risk factors for tumor or tumor-like disease. It is worthy to mention that endometriosis shows some malignancy behaviors such as local invasion and genetic changes .
KeywordsEndometriosis Blood Group Project Design Blood Type Southern Population
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