Abstract
Objective
T-cadherin is a tumor-suppressor with low expression in many malignant tumors, but with high expression in endothelial cells and so on. In this study we investigated whether T-cadherin was expressed and if together with bFGF play a role in the occurrence and development of uterine leiomyoma.
Method
Uterine leiomyoma, the adjacent normal myometrium, control normal myometrium without uterine leiomyoma and vascular features of myoma were collected. Immunohistochemistry, western blot and relative quantitative real time PCR were used to evaluate bFGF and T-cadherin on the three specimens. Data were statistically analysed.
Results
T-cadherin was observed on the leiomyoma cellular layers but not in the endochylema, extracellular matrix and leiomyoma vascular endothelial cell, bFGF in the leiomyoma endochylema but not observed in the extracellular matrix and leiomyoma vascular endothelial cell. The protein and mRNA expression of bFGF and T-cadherin in uterine leiomyoma were significantly with higher expression than that in adjacent normal myometrium and control normal myometrium. In addition, T-cadherin correlated well with bFGF. There was relationship between T-cadherin and color Doppler flow imaging (CDFI).
Conclusion
bFGF and T-cadherin have high expressions in uterine leiomyoma, and T-cadherin is associated with CDFI, indicating that a cross talk between bFGF and T-cadherin plays an important role in the occurrence and development of uterine leiomyoma or even malignant tumors.
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Conflict of interest
We think that the most interesting result of this study is that the current study presents three key results. First, T-cadherin was high-expression in the leiomyoma cellular layers, extracellular matrix and small artery. Second, T-cadherin expressed higher than that in adjacent myometrium and control normal myometrium. Last, T-cadherin and bFGF appeared to play an important role in angiogenesis and proliferation in uterine leiomyoma.
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Wang, L., Mou, X., Xiao, L. et al. T-cadherin expression in uterine leiomyoma. Arch Gynecol Obstet 288, 607–614 (2013). https://doi.org/10.1007/s00404-013-2732-0
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DOI: https://doi.org/10.1007/s00404-013-2732-0