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Association of parity with osteoprotegerin levels and atherosclerosis

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Association of serum osteoprotegerin (OPG) levels and cardiovascular disorders has been shown previously. The aim of this observational study was to investigate the relationship between parity, OPG and carotid intima-media thickness (CIMT) in premenopausal women.

Methods

A total of 128 women (mean age ± SD, 37.8 ± 4.7 years) were divided into three group according to parity [1–3 as group 1 (n = 41), 4–6 as group 2 (n = 55) and ≥7 as group 3 (n = 32)]. Serum OPG was measured and CIMT was evaluated.

Results

Both serum OPG levels and CIMT tended to increase with advancing parity; OPG level was significantly higher in group 3 than in group 1 (p = 0.013) and CIMT was significantly higher in group 2 and group 3 than in group 1 (p < 0.001 for both). In correlation analyses, there were significant correlations between all three parameters.

Conclusions

Our results revealed that there was an increased risk of cardiovascular disease in women with multiparity. Significant association of OPG with CIMT suggested that OPG might play a role in the pathogenesis of parity-induced atherosclerosis.

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Authors and Affiliations

  1. Department of Endocrinology, School of Medicine, Faculty of Medicine, Harran University, Yenisehir Campus, Sanliurfa, 63300, Turkey

    Mehmet Ali Eren

  2. Department of Obstetrics and Gynecology, School of Medicine, Harran University, Sanliurfa, Turkey

    Mehmet Vural, Hakan Camuzcuoglu & Harun Toy

  3. Department of Radiology, School of Medicine, Harran University, Sanliurfa, Turkey

    Sema Yildiz & Hasan Cece

  4. Department of Clinical Biochemistry, School of Medicine, Harran University, Sanliurfa, Turkey

    Abdurrahim Kocyigit

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  1. Mehmet Ali Eren
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  2. Mehmet Vural
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Correspondence to Mehmet Ali Eren.

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Eren, M.A., Vural, M., Yildiz, S. et al. Association of parity with osteoprotegerin levels and atherosclerosis. Arch Gynecol Obstet 287, 1081–1086 (2013). https://doi.org/10.1007/s00404-012-2703-x

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  • DOI: https://doi.org/10.1007/s00404-012-2703-x

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