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Prevalence of human papillomavirus (HPV) among college going girls using self collected urine samples from Tiruchirappalli, Tamilnadu

  • General Gynecology
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Abstract

Purpose

The study aimed to identify the status of HPV infection among young sexually unexposed girls from Tiruchriapalli district, Tamilnadu, India.

Methods

The distribution of HPV genotypes was evaluated by PCR DNA genotyping after self sampling from 246 study subjects.

Results

Positivity for HPV DNA was reported among 9.2 % of the study subjects. The most frequently detected HPV type was HPV 16 (0.8 %) followed by HPV 11 (0.4 %).

Conclusion

Our results suggest that the age did not seem to be a cofactor for HPV infection and nevertheless, sexual intercourse is an important factor for HPV infection. Moreover, these results demonstrate that HPV detection performed in self collected samples may be important to appraise better preventive strategies and monitor the influence of vaccination programmes within the population.

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References

  1. Moscicki AB, Grubbs Burt V, Kanowitz S, Darragh T, Shiboski S (1999) The significance of squamous metaplasia in the development of low grade squamous intraepithelial lesions in young women. Cancer 85:1139–1144

    Article  PubMed  CAS  Google Scholar 

  2. Woodman CBJ, Collins SI, Young LS (2007) The natural history of cervical HPV infection: unresolved issues. Nat Rev Can 7:11–22

    Article  CAS  Google Scholar 

  3. Hausen HZ (2009) Human papillomavirus and cervical cancer. Ind J Med Res 130:209

    Google Scholar 

  4. Lenselink CH, Melchers WJ, Quint WG, Hoebers AM, Hendriks JC, Massuger LF (2008) Sexual behaviour and HPV infections in 18–29 year old women in the pre-vaccine era in the Netherlands. PLoS ONE 3:e3743

    Article  PubMed  Google Scholar 

  5. Winer RL, Lee SK, Hughes JP, Adam DE, Kiviat NB, Koutsky LA (2003) Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students. Am J Epidemiol 157:218–226

    Article  PubMed  Google Scholar 

  6. Naud P, Matos J, Hammes L, Stuckzynski J, Brouwers K, Magno V (2006) Factors predicting intermediate endpoints of cervical cancer and exposure to human papillomavirus (HPV) infections in young women screened as potential targets for prophylactic HPV vaccination in south of Brazil. Eur J Obst Gynecol Rep Biol 124:110–118

    Article  CAS  Google Scholar 

  7. Frega A, Cenci M, Stentella P (2003) Human papillomavirus in virgins and behaviour at risk. Cancer Lett 194:21–24

    Article  PubMed  CAS  Google Scholar 

  8. Frega A, Stentella P, De Ioris A (2003) Young women, cervical intraepithelial neoplasia and human papillomavirus: risk factors for persistence and recurrence. Cancer Lett 196:127–134

    Article  PubMed  CAS  Google Scholar 

  9. Petignat P, Faltin DL, Bruchim I, Tramer MR, Franco EL, Coutlee F (2007) Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review andmeta-analysis. Gynecologic Oncol 105:530–535

    Article  Google Scholar 

  10. Hobbs MM, Van Der Pol B, Totten P (2008) From the NIH: proceedings of a workshop on the importance of self-obtained vaginal specimens for detection of sexually transmitted infections. Sex Trans Dis 35:8–13

    Article  Google Scholar 

  11. Villa LL (2006) Prophylactic HPV vaccines: reducing the burden of HPV-related diseases. Vaccine 24:23–28

    Article  Google Scholar 

  12. Pretorius RG, Belinson JL (2007) Letter to the Editor concerning Petignat et al’.s Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and metaanalysis. Gynecologic Oncol 107:595–596

    Article  Google Scholar 

  13. Prusty BK, Kumar A, Arora R, Batra S, Das BC (2005) Human Papillomavirus (HPV) DNA detection in self-collected urine. Int J Gynecol Obst 90:223–227

    Article  CAS  Google Scholar 

  14. Boom R, Sol CJA, Salimaus MMM, Jansen CL, Dillen PME, Noordaa JVD (1990) Rapid and simple method for purification of nucleic acids. J Clin Microbiol 28:495–503

    PubMed  CAS  Google Scholar 

  15. Gopalkrishna V, Francis A, Sharma JK, Das BC (1992) A simple andrapid method of high quality DNA isolation from cervical scrapes for detection of human papillomavirus infection. J Virol Met 36:63

    Article  CAS  Google Scholar 

  16. Forslund O, Hansson BG, Rymark P, Bjerre B (1993) Human papillomavirus DNA in urine samples compared with that in simultaneously collected urethra and cervix samples. J Clin Microbiol 31:1975–1979

    PubMed  CAS  Google Scholar 

  17. Snijders PJF, Van den Brule AJC, Schrinjnemakers HJF, Snow G, Meijer CJLM, Walboomers JMM (1990) The use of general primers in the polymerase chain reaction permits the detection of broad spectrum of HPV genotypes. J Gen Virol 71:173–181

    Article  PubMed  CAS  Google Scholar 

  18. Das BC, Gopalkrishna V, Sharma JK, Roy M, Luthra UK (1992) Human papillomavirus DNA in urine of women with preneoplastic and neoplastic cervical lesions. The Lancet 340:1417–1418

    Article  CAS  Google Scholar 

  19. Ludicke F, Stalberg A, Vassilakos P, Major AL, Campana A (2001) High- and intermediate-risk human papillomavirus infection in sexually active adolescent females. J Ped Adol Gynecol 14:171–174

    Article  CAS  Google Scholar 

  20. Bartholomew DA (2004) Human papillomavirus infection in adolescents: a rational approach. Adol Med Clin 15:569–595

    Article  Google Scholar 

  21. Ho GYF, Bierman R, Beardsley L, Chang CJ, Burk RD (1998) Natural history of cervicovaginal papillomavirus infection in young women. The New England Journal of Medicine 338:423–428

    Article  PubMed  CAS  Google Scholar 

  22. Moscicki AB, Hills N, Shiboski S (2001) Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. J Am Med Assoc 285:2995–3002

    Article  CAS  Google Scholar 

  23. Trottier H, Franco EL (2006) The epidemiology of genitalhuman papillomavirus infection. Vaccine 24:4–15

    Article  Google Scholar 

  24. Dunne EF, Unger ER, Sternberg M (2007) Prevalence of HPV infection among females in the United States. J Am Med Assoc 297:813–819

    Article  CAS  Google Scholar 

  25. Burk RD, Ho GFY, Beardsley L, Lempa M, Peters M, Bierman R (1996) Sexual behavior and partner characteristics are the predominant risk factors for genital human papillomavirus infection in young women. J Infect Dis 174:679–689

    Article  PubMed  CAS  Google Scholar 

  26. Kotloff KL, Wasserman SS, Russ K (1998) Detection of genital human papillomavirus and associated cytological abnormalities among college women. Sex Trans Dis 25:243–250

    Article  CAS  Google Scholar 

  27. Janicek MF, Averette HE (2001) Cervical cancer: prevention, diagnosis, and therapeutics. Can J Clin 51:92–114

    Article  CAS  Google Scholar 

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Acknowledgments

KNS greatly acknowledge Indian Council of Medical Research (ICMR), New-Delhi for the financial support in order to carry out this study (No. 5/13/88/06 -NCD –III). We remain thankful to the Vice-Chancellor, Bharathidasan University for provision of facilities.

Conflict of interest

The authors of the manuscript have no conflict of interest.

Author information

Authors and Affiliations

  1. Medical Microbiology Laboratory, Department of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620024, India

    A. Thilagavathi, S. Shanmughapriya, K. Vinodhini & K. Natarajaseenivasan

  2. Dr.B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, 110007, India

    B. C. Das

Authors
  1. A. Thilagavathi
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  2. S. Shanmughapriya
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  3. K. Vinodhini
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  4. B. C. Das
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  5. K. Natarajaseenivasan
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Corresponding author

Correspondence to K. Natarajaseenivasan.

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Thilagavathi, A., Shanmughapriya, S., Vinodhini, K. et al. Prevalence of human papillomavirus (HPV) among college going girls using self collected urine samples from Tiruchirappalli, Tamilnadu. Arch Gynecol Obstet 286, 1483–1486 (2012). https://doi.org/10.1007/s00404-012-2500-6

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  • DOI: https://doi.org/10.1007/s00404-012-2500-6

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