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Hyaluronan binding assay does not predict pregnancy rates in IUI cycles in couples with unexplained infertility

  • Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To investigate the relationship between hyaluronan binding (HB) assay and pregnancy rates in intrauterine insemination (IUI) cycles.

Methods

This prospective cohort study was done in Hacettepe University, a tertiary care center for reproductive medicine. Seventy-one consecutive couples who suffered from unexplained infertility and underwent controlled ovarian hyperstimulation (COH) and IUI were enrolled into the study.

Results

From the 71 IUI patients, the clinical pregnancy rate was 14.1 % (10 of 71). HB ratio from the overall patient number was 48.6 ± 25.9. The mean HB ratio in pregnant and non-pregnant groups was comparable (50.2 ± 25.2 vs. 48.3 ± 26.2, respectively, p > 0.05).

Conclusions

Hyaluronan binding assay does not predict pregnancy rates in IUI cycles in couples with unexplained infertility.

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References

  1. Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, Carson SA, Cisneros P, Steinkampf MP, Hill JA, Xu D, Vogel DL (2001) Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 345(19):1388–1393. doi:10.1056/NEJMoa003005

    Article  PubMed  CAS  Google Scholar 

  2. Agarwal A, Said TM (2003) Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update 9(4):331–345

    Article  PubMed  CAS  Google Scholar 

  3. Bastiaan HS, Windt ML, Menkveld R, Kruger TF, Oehninger S, Franken DR (2003) Relationship between zona pellucida-induced acrosome reaction, sperm morphology, sperm-zona pellucida binding, and in vitro fertilization. Fertil Steril 79(1):49–55

    Article  PubMed  Google Scholar 

  4. Davis RO, Katz DF (1993) Operational standards for CASA instruments. J Androl 14(5):385–394

    PubMed  CAS  Google Scholar 

  5. Drahorad J, Tesarik J, Cechova D, Vilim V (1991) Proteins and glycosaminoglycans in the intercellular matrix of the human cumulus-oophorus and their effect on conversion of proacrosin to acrosin. J Reprod Fertil 93(2):253–262

    Article  PubMed  CAS  Google Scholar 

  6. Huszar G, Ozenci CC, Cayli S, Zavaczki Z, Hansch E, Vigue L (2003) Hyaluronic acid binding by human sperm indicates cellular maturity, viability, and unreacted acrosomal status. Fertil Steril 79(Suppl 3):1616–1624

    Article  PubMed  Google Scholar 

  7. Huszar G, Ozkavukcu S, Jakab A, Celik-Ozenci C, Sati GL, Cayli S (2006) Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential: selection of sperm for intracytoplasmic sperm injection. Curr Opin Obstet Gynecol 18(3):260–267. doi:10.1097/01.gco.0000193018.98061.2f

    Article  PubMed  Google Scholar 

  8. Jakab A, Sakkas D, Delpiano E, Cayli S, Kovanci E, Ward D, Revelli A, Huszar G (2005) Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies. Fertil Steril 84(6):1665–1673. doi:10.1016/j.fertnstert.2005.05.068

    Article  PubMed  Google Scholar 

  9. Kovacs P, Kovats T, Sajgo A, Szollosi J, Matyas S, Kaali SG (2011) The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility. J Assist Reprod Genet 28(1):49–54. doi:10.1007/s10815-010-9479-3

    Article  PubMed  Google Scholar 

  10. Ye H, Huang GN, Gao Y, de Liu Y (2006) Relationship between human sperm–hyaluronan binding assay and fertilization rate in conventional in vitro fertilization. Hum Reprod 21(6):1545–1550. doi:10.1093/humrep/del008

    Article  PubMed  CAS  Google Scholar 

  11. Nijs M, Creemers E, Cox A, Janssen M, Vanheusden E, Van der Elst J, Ombelet W (2010) Relationship between hyaluronic acid binding assay and outcome in ART: a pilot study. Andrologia 42(5):291–296. doi:10.1111/j.1439-0272.2009.00992.x

    Article  PubMed  Google Scholar 

  12. Parmegiani L, Cognigni GE, Bernardi S, Troilo E, Ciampaglia W, Filicori M (2010) “Physiologic ICSI”: hyaluronic acid (HA) favors selection of spermatozoa without DNA fragmentation and with normal nucleus, resulting in improvement of embryo quality. Fertil Steril 93(2):598–604. doi:10.1016/j.fertnstert.2009.03.033

    Article  PubMed  Google Scholar 

  13. Tarozzi N, Nadalini M, Bizzaro D, Serrao L, Fava L, Scaravelli G, Borini A (2009) Sperm–hyaluronan-binding assay: clinical value in conventional IVF under Italian law. Reprod Biomed Online 19(Suppl 3):35–43

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Anatolia IVF Center, Ankara, Turkey

    Fazilet Kubra Boynukalin

  2. Division of Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Ibrahim Esinler & Serdar Gunalp

  3. Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey

    Suleyman Guven

Authors
  1. Fazilet Kubra Boynukalin
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  2. Ibrahim Esinler
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  3. Suleyman Guven
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  4. Serdar Gunalp
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Corresponding author

Correspondence to Ibrahim Esinler.

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Boynukalin, F.K., Esinler, I., Guven, S. et al. Hyaluronan binding assay does not predict pregnancy rates in IUI cycles in couples with unexplained infertility. Arch Gynecol Obstet 286, 1577–1580 (2012). https://doi.org/10.1007/s00404-012-2476-2

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  • DOI: https://doi.org/10.1007/s00404-012-2476-2

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