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The impact of human papillomavirus (HPV) types 6, 11 in women with genital warts

Archives of Gynecology and Obstetrics volume 286, pages 1261–1267 (2012)Cite this article

Abstract

Objective

Human papillomaviruses (HPV) are etiologically associated with the development of virtually all genital warts. HPV-6 and HPV-11 are the most commonly detected HPV genotypes, but at least 20 other HPV genotypes have occasionally been found in genital wart tissue specimens.

Study design

The aim of this study was to determine from 100 genital wart tissue specimens collected from female patients using multiplex gap-PCR technique the prevalence of various genital HPV among women with HPV genital warts in south of Iran. 100 genital wart tissue specimens were tested for the presence of HPV PG5/PG6 and also for HPV type using polymerase chain reaction (PCR).

Results

Based on the collected data, 73 (73 %) samples were detected positive for HPV DNA and 23 (23 %) samples out of 100 samples were detected negative for HPV DNA. 49 (49 %) and 67 (67 %) of patients were detected positive for HPV type 6 and 11, respectively. There was a significant association between marital status and HPV genotype 6 (OR = 0.51, 95 % CI = 0.37–0.70, P = 0.01). Nevertheless, no significant association was found between marriage and HPV genotype 11 (OR = 0.85, 95 % CI = 0.58–1, 24, P = 0.7). Similarly, this result was demonstrated, in combined marriage and HPV-general (OR = 0.80, 95 % CI = 0.62–0.05, P = 0.4).

Conclusion

Concerning the prevalence of HPV in our study, determination of genital HPV prevalence and multiple infections among the normal population of women of Hormozgan Province is recommended.

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Acknowledgments

The authors wished to thank all the staff and patients who took part in the study. We are also thankful to Dr. F. Jamshidy for providing us the clinical samples, and are also thankful to infection and molecular medicine research centers for supporting this project financially.

Conflict of interest

The authors declare that there is no conflict of interest.

Author information

Affiliations

  1. Research Center for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar-Abbas, Iran

    Mohammad Shekari, Abdol Azim Nejatizadeh, Keyanoush Malekzadeh, Mahnaz Baghershiroodi & Farzaneh Dehghan

  2. Infections Research Center, Hormozgan University of Medical Sciences, Bandar-Abbas, Iran

    Mahin Jamshidi, Mohammad Shekari, Abdol Azim Nejatizadeh & Parivash Davudian

  3. Dermatology Private Clinic, Bandar-Abbas, Iran

    Froogh Jamshidi

Authors
  1. Mahin Jamshidi
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  2. Mohammad Shekari
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  3. Abdol Azim Nejatizadeh
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  4. Keyanoush Malekzadeh
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  5. Mahnaz Baghershiroodi
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  8. Froogh Jamshidi
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Corresponding author

Correspondence to Mohammad Shekari.

Additional information

M. Jamshidi and M. Baghershiroodi contributed equally as first authors.

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Jamshidi, M., Shekari, M., Nejatizadeh, A.A. et al. The impact of human papillomavirus (HPV) types 6, 11 in women with genital warts. Arch Gynecol Obstet 286, 1261–1267 (2012). https://doi.org/10.1007/s00404-012-2416-1

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  • DOI: https://doi.org/10.1007/s00404-012-2416-1

Keywords

  • Human papillomavirus
  • Genital warts
  • PCR
  • Typing