Archives of Gynecology and Obstetrics

, Volume 286, Issue 4, pp 947–952 | Cite as

Skin adhesive low-level light therapy for dysmenorrhoea: a randomized, double-blind, placebo-controlled, pilot trial

  • Yong-Il Shin
  • Nam-Gyun KimEmail author
  • Kyoung-Jun Park
  • Dong-Wook Kim
  • Gi-Youn Hong
  • Byung-Cheul Shin
General Gynecology



The cause of dysmenorrhoea is an abnormal function of smooth muscles in the uterus due to long-term deficient blood supply into smooth muscle tissue. The purpose of this study was to evaluate the effectiveness of skin adhesive low-level light therapy (LLLT) in participants with dysmenorrhoea.


Thirty-one women were included in this randomized, double-blind, placebo-controlled, pilot trial. Twenty-one women were treated with active LLLT and ten women were treated with placebo one. The therapy was performed in a laboratory room for 20 min a day over a period of 5 days prior to the expected onset of menstruation. The outcome was measured using a visual analog scale (VAS) for each participant’s dysmenorrhoeal pain severity. VAS of each subject was measured every month for 6 months.


In the active LLLT group, 16 women reported successful results during their first menstrual cycle just after active LLLT and 5 women had successful results from the second menstrual cycle after active LLLT. The pain reduction rate was 83 % in the active LLLT group, whereas there was only a slight and temporary reduction in pain in the placebo LLLT group. Changes of VAS within 6 months of LLLT showed statistical significance (p = 0.001) over placebo control.


Our study suggests that skin adhesive LLLT on acupuncture points might be an effective, simple and safe non-pharmacological treatment for dysmenorrhoea.


Low-level light therapy Dysmenorrhoea Acupuncture point Smooth muscle relaxation 



This work was supported by the Grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Center for Healthcare Technology Development). All devices used in this study were supported by Color Seven Company.

Conflict of interest

All authors declare that they have no conflict of interest.


  1. 1.
    Cakir M, Mungan I, Karakas T, Girisken I, Okten A (2007) Menstrual pattern and common menstrual disorders among university students in Turkey. Pediatr Int 49(6):938–942PubMedCrossRefGoogle Scholar
  2. 2.
    Sharma A, Taneja DK, Sharma P, Saha R (2012) Socioeconomic correlates of reproductive morbidity among adolescent girls in Sikkim. India Asia Pac J Public Health 24:136–150CrossRefGoogle Scholar
  3. 3.
    Smith RP, Kaunitz AM, Barbieri RL, Barss VA (2011) Pathogenesis, clinical manifestations, and diagnosis of primary dysmenorrhea in adult women. Accessed 01 Dec 2011
  4. 4.
    Banikarim C, Middleman AB, Geffner M, Hoppin AG (2011) Primary dysmenorrhea in adolescents. Accessed 01 Dec 2011
  5. 5.
    Burton WN, Morrison A, Wertheimer AI (2003) Pharmaceuticals and worker productivity loss: a critical review of the literature. J Occup Environ Med 45(6):610–621PubMedCrossRefGoogle Scholar
  6. 6.
    Bulletti C, DE Ziegler D, Setti PL, Cicinelli E, Polli V, Flamigni C (2004) The patterns of uterine contractility in normal menstruating women: from physiology to pathology. Ann N Y Acad Sci 1034:64–83PubMedCrossRefGoogle Scholar
  7. 7.
    Mueller A, Maltaris T, Siemer J, Binder H, Hoffmann I, Beckmann MW, Dittrich R (2006) Uterine contractility in response to different prostaglandins: results from extracorporeally perfused non-pregnant swine uteri. Hum Reprod 21(8):2000–2005PubMedCrossRefGoogle Scholar
  8. 8.
    Berkow R (1992) The Merck manual of diagnosis and therapy, 16th edn. Merck Research Laboratories, New JerseyGoogle Scholar
  9. 9.
    Eby GA (2007) Zinc treatment prevents dysmenorrhea. Med Hypotheses 69(2):297–301PubMedCrossRefGoogle Scholar
  10. 10.
    Marjoribanks J, Proctor M, Farquhar C, Derks RS (2010) Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev 20(1):CD001751 ReviewGoogle Scholar
  11. 11.
    Tramer MR, Moore RA, Reynolds DJ, McQuay HJ (2000) Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use. Pain 85(1–2):169–182PubMedCrossRefGoogle Scholar
  12. 12.
    Smith KC (2010) Laser and LED photobiology. Laser Therapy 19(2):72–78CrossRefGoogle Scholar
  13. 13.
    Tiphlova O, Karu T (1988) Stimulation of Escherichia coli division by low-intensity monochromatic visible light. Photochem Photobiol 48(4):467–471PubMedCrossRefGoogle Scholar
  14. 14.
    Ball KA, Castello PR, Poyton RO (2011) Low intensity light stimulates nitrite-dependent nitric oxide synthesis but not oxygen consumption by cytochrome c oxidase: implications for phototherapy. J Photochem Photobiol B 102(3):182–191PubMedCrossRefGoogle Scholar
  15. 15.
    Witt CM, Reinhold T, Brinkhaus B, Roll S, Jena S, Willich SN (2008) Acupuncture in patients with dysmenorrhea: a randomized study on clinical effectiveness and cost-effectiveness in usual care. Am J Obstet Gynecol 198(2):166.e1–166.e8CrossRefGoogle Scholar
  16. 16.
    Schiøtz HA, Jettestad M, Al-Heeti D (2007) Treatment of dysmenorrhoea with a new TENS device (OVA). J Obstet Gynaecol 27(7):726–728PubMedCrossRefGoogle Scholar
  17. 17.
    Jones KR, Vojir CP, Hutt E, Fink R (2007) Determining mild, moderate, and severe pain equivalency across pain-intensity tools in nursing home residents. J Rehabil Res Dev 44(2):305–314PubMedCrossRefGoogle Scholar
  18. 18.
    Editorial committee of the Korean Acupuncture and Moxibustion Society (2008) The acupuncture and moxibustion. Zipmundang, Seoul In KoreanGoogle Scholar
  19. 19.
    Kelly AM (1998) Does the clinically significant difference in visual analogue scale pain scores vary with gender, age, or cause of pain? Acad Emerg Med 5(11):1086–1090PubMedCrossRefGoogle Scholar
  20. 20.
    Abbott J, Hawe J, Srivastava P, Hunter D, Garry R (2001) Intraperitoneal gas drain to reduce pain after laparoscopy: randomized masked trial. Obstet Gynecol 98(1):97–100PubMedCrossRefGoogle Scholar
  21. 21.
    Kempf D, Berger D, Ausfeld-Hafter B (2009) Laser needle acupuncture in women with dysmenorrhoea: a randomised controlled double blind pilot trial. Forsch Komplementmed 16(1):6–12PubMedCrossRefGoogle Scholar
  22. 22.
    Kataoka M, Togashi K, Kido A, Nakai A, Fujiwara T, Koyama T, Fujii S (2005) Dysmenorrhea: evaluation with cine-mode-display MR imaging—initial experience. Radiology 235(1):124–131PubMedCrossRefGoogle Scholar
  23. 23.
    Kido A, Togashi K, Kataoka M, Maetani Y, Nakai A, Kataoka ML, Koyama T, Fujii S (2007) The effect of oral contraceptives on uterine contractility and menstrual pain: an assessment with cine MR imaging. Hum Reprod 22(7):2066–2071PubMedCrossRefGoogle Scholar
  24. 24.
    Wyatt K, Dimmock P, Jones P, Obhrai M, O’Brien S (2001) Efficacy of progesterone and progestogens in management of premenstrual syndrome: systematic review. BMJ 323(7316):776–780PubMedCrossRefGoogle Scholar
  25. 25.
    Cerin A, Colilins A, Landgren BM, Eneroth P (1993) Hormonal and biochemical profiles of premenstrual syndrome. Acta Obstet Gynecol Scand 72(5):337–343PubMedCrossRefGoogle Scholar
  26. 26.
    Kelly JV (1962) Myometrical participation in human sperm transport: a dilemma. Fertil Steril 12:84–92Google Scholar
  27. 27.
    Bulletti C, de Ziegler D, Polli V, Diotallevi L, Del Ferro E, Flamigni C (2000) Uterine contractility during the menstrual cycle. Hum Reprod 15(Suppl 1):81–89PubMedCrossRefGoogle Scholar
  28. 28.
    Soh KS (2004) Bonghan duct and acupuncture meridian as optical channel of biophoton. J Korean Phys Soc 45(5):1196–1198Google Scholar
  29. 29.
    Kim SS (1989) Pyun-jac royal guide I: acupuncture and moxibustion. Kim Sung Han Inc., Seoul In KoreanGoogle Scholar
  30. 30.
    Pankratov S (1991) Meridian conduct light. Raum und Zeit 35(88):16–18 In GermanGoogle Scholar
  31. 31.
    Karu T (1986) Biological action of low-intensity visible monochromatic light and some of its medical applications. In: Galletti G (ed) Laser. Monduzzi Editore, Bologna, pp 25–29Google Scholar
  32. 32.
    Yap LR (2006) Raciometric imaging of calcium in myometrial cells. Neurobiology-Physiology Major Report, University of Maryland, College Park. Accessed 01 Dec 2011
  33. 33.
    Poyton RO, Ball KA (2011) Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase. Discov Med 11(57):154–159PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Yong-Il Shin
    • 1
  • Nam-Gyun Kim
    • 2
    Email author
  • Kyoung-Jun Park
    • 2
  • Dong-Wook Kim
    • 2
  • Gi-Youn Hong
    • 3
  • Byung-Cheul Shin
    • 4
  1. 1.Department of Rehabilitation Medicine, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea
  2. 2.Department of Healthcare Engineering, Graduate SchoolChonbuk National UniversityJeonjuKorea
  3. 3.Department of Obstetrics and GynecologyWonkwang University School of Medicine, Wonkwang University HospitalIksanKorea
  4. 4.Division of Clinical Medicine, School of Korean MedicinePusan National UniversityYangsanKorea

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