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Detection and genotyping of cervical HPV with simultaneous cervical cytology in Turkish women: a hospital-based study

Archives of Gynecology and Obstetrics volume 286, pages 203–208 (2012)Cite this article

Abstract

Purpose

To investigate the prevalence of cervical human papilloma virus (HPV) with genotyping and simultaneous cervical cytology among Turkish women in a university hospital. A review of literature was done as well to summarize the results of similar Turkish studies based on hospital data.

Methods

Women who were subjected to cervical HPV-DNA testing with simultaneous cervical Pap test were included. Seeplex HPV 18-plex Genotyping Test was used for HPV detection and typing. Liquid-based cytology was used for Pap test and Bethesda system was used for results.

Results

Study group included 890 patients with a mean age of 39.5 years. The prevalence of any HPV was 25.7% while high-risk HPV was positive in 23.0%. There were no significant differences in HPV prevalence between younger and older women. Among HPV-positive women, 89.5% had at least one type of high-risk HPV. Most common HPV was type 16 followed by type 31 and 51. Abnormal cervical cytology rate was 11.6%. Rate of HPV positivity was significantly higher in women with abnormal cervical cytology compared to women with normal cytology (54.4 vs. 22.0%).

Conclusions

Cervical HPV infection is a serious and gradually growing problem for Turkish women according to hospital-based data. This may be associated with low age at marriage and more sensitive HPV detection methods.

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Conflict of interest

We declare that we have no conflict of interest.

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Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Sihhiye, 06100, Ankara, Turkey

    Kunter Yuce, Mehmet Coskun Salman, Berkan Sayal & Selen Dogan

  2. Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

    Ahmet Pinar, Alpaslan Alp & Gulsen Hascelik

Authors
  1. Kunter Yuce
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  2. Ahmet Pinar
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  3. Mehmet Coskun Salman
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  4. Alpaslan Alp
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  5. Berkan Sayal
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  6. Selen Dogan
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  7. Gulsen Hascelik
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Corresponding author

Correspondence to Mehmet Coskun Salman.

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Yuce, K., Pinar, A., Salman, M.C. et al. Detection and genotyping of cervical HPV with simultaneous cervical cytology in Turkish women: a hospital-based study. Arch Gynecol Obstet 286, 203–208 (2012). https://doi.org/10.1007/s00404-012-2280-z

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  • DOI: https://doi.org/10.1007/s00404-012-2280-z

Keywords

  • Cervical cancer
  • Human papilloma virus
  • Pap smear
  • Turkey