To evaluate the clinical and mycological cure rates of a novel mixture consisting of Bee-honey and yogurt compared to local antifungal agents for treating patients with vulvo-vaginal candidiasis (VVC) during pregnancy.
Materials and methods
This is a prospective comparative study which included 129 patients with VVC during pregnancy. The participants were allocated into study group (n = 82) who received a mixture of Bee-honey and yogurt vaginally and control group (n = 47) who received local anti-fungal agents. The Chi-square test was used to evaluate the clinical and mycological cure rates and the side-effects of both modes of therapy.
The clinical cure rate was significantly higher in the study than the control group (87.8 vs. 72.3%, respectively) while the mycological cure rate was higher in the control than the study group (91.5 vs. 76.9%, respectively). Both types of therapy were favorably tolerated by most of the patients. Side effects were reported only in 24.3 and 29.7% of patients in group I and II, respectively (p < 0.05).
The mixture of Bee-honey and yogurt produced a high clinical cure rate and a reasonable mycological cure rate. It can be used as a complementary or an alternative to antifungal agents especially in patients with VVC during pregnancy.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Irish J, Carter D, Shokohi T, Blair S (2006) Honey has an antifungal effect against Candida species. Med Mycol 44(3):289–291
Sobel J, Faro S, Force R et al (1998) Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. Am J Obstet Gynecol 179(2):557–558
Nyirjesy P (2001) Chronic vulvovaginal candidiasis. Am Fam Physician 63(4):697–702
Soong D, Einarson A (2009) Vaginal yeast infections during pregnancy. Can Fam Physician 55:255–256
Jeavons H (2003) Prevention and treatment of vulvovaginal candidiasis using exogenous Lactobacillus. J Obstet Gynecol Neonatal Nurs 32(3):287–296
Falagas M, Betsi G, Athanasiou S (2006) Probiotics for prevention of recurrent vulvovaginal candidiasis: a review. J Antimicrob Chemother 58(2):266–272
King CT, Rogers PD, Cleary JD, Chapman SW (1998) Antifungal therapy during pregnancy. Clin Infect Dis 27(5):1151–1160
Young GL, Jewell D (2001) Topical treatment for vaginal candidiasis (thrush) in pregnancy. Cochrane Database Syst Rev 4:CD000225. doi:10.1002/14651858.CD000225
Lee BE, Feinberg M, Abraham JJ, Murthy AR (1992) Congenital malformations in an infant born to a woman treated with fluconazole. Pediatr Infect Dis J 11(12):1062–1064
Pursley TJ, Blomquist IK, Abraham J, Andersen HF, Bartley JA (1996) Fluconazole-induced congenital anomalies in three infants. Clin Infect Dis 22(2):336–340
Al Waili N (2004) Investigating the antimicrobial activity of natural honey and its effects on the pathogenic bacterial infections of surgical wounds and conjunctiva. J Med Food 7(2):210–222
Zumla A, Lulat A (1989) Honey—a remedy rediscovered. J R Soc Med 82(7):384–385
Wahdan H (1998) Causes of the antimicrobial activity of honey. Infection 26(1):26–31
Molan PC (1992) The antibacterial activity of honey: 2. Variation in the potency of the antibacterial activity. Bee World 73:59–76
Finola MS, Lasagno MC, Marioli JM (2007) Microbial and chemical characterization of honeys from central Argentina. Food Chem 100:1649–1653
Sissons CH, Anderson SA, Molan PC (2004) Suppression of C. albicans in plaque microcosms by manuka honey. In: IADR/AADR/CADR 82nd General Session in Honolulu, Hawai, 2004
Boukraa L, Benbarek H, Mossa A (2008) Synergistic action of starch and honey against Candida albicans in correlation with diastase number. Brazil J Microbiol 39:40–43
Al-Waili NS (2005) Mixture of honey, beeswax and olive oil inhibits growth of Staphylococcus aureus and C. albicans. Arch Med Res 36:10–13
Koc AN, Silic S, Ercal BD, Kasap F, Hormet-Oz HT, Buldu HM (2009) Antifungal activity of Turkish honey against Candida spp. and Trichosporon spp: an in vitro evaluation. Med Mycol 47:707–712
Osset J, Garcia E, Bartolome R, Andreu A (2001) Role of Lactobacillus as protector against vaginal candidiasis. Med Clin 117(8):285–288
Williams A (2002) Yogurt: still a favorite for vaginal candidiasis? J Nat Med Assoc 94(4):A10
Holmberg K, Meyer RD (1989) Diagnosis and therapy of systemic fungal infections. Raven Press, New York
Dun E (1999) Antifungal resistance in yeast vaginitis. Yale J Biol Med 72(3):281–285
Conflict of interest
We declare that we have no conflict of interest.
About this article
Cite this article
Abdelmonem, A.M., Rasheed, S.M. & Mohamed, A.S. Bee-honey and yogurt: a novel mixture for treating patients with vulvovaginal candidiasis during pregnancy. Arch Gynecol Obstet 286, 109–114 (2012). https://doi.org/10.1007/s00404-012-2242-5