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Lack of correlation between first trimester maternal serum 25-hydroxyvitamin D levels and ultrasound measured crown-rump length and nuchal translucency

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Abstract

Background

Vitamin D regulates the human genome and it is thought to influence the fetal growth and development, but its relation to early ultrasound fetal measures is still unknown.

Objective

To assess first trimester 25-hydroxyvitamin D [25(OH)D] maternal serum status and correlate with ultrasound crown-rump length (CRL) and nuchal translucency (NT) measurements.

Method

In this cross-sectional study, women with singleton pregnancies undergoing the first trimester standard two-dimensional ultrasound scan for fetal anomalies were included: CRL (n = 498) and NT (n = 487). Concomitantly, maternal serum 25(OH)D levels were also measured.

Results

Median serum 25(OH)D levels for the entire sample (n = 498) was 27.4 ng/mL (interquartile range 20.9–32.7). Serum 25(OH)D was adequate (≥30 ng/mL) in only 36.1% of gravids, whereas levels were found to be insufficient (20–29.99 ng/mL) in 41.2% and deficient (<20 ng/mL) in 22.7%. No significant correlation was found between the serum 25(OH)D levels and the measured ultrasound parameters.

Conclusion

First trimester 25(OH)D levels did not correlate to fetal ultrasound measurements.

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Acknowledgments

The study was partially supported by the “Fundación Progreso y Salud” PI-0359 grant from the “Junta de Andalucía”, Spain.

Conflict of interest

The authors report no conflicts of interest.

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Authors and Affiliations

  1. Departamento de Obstetricia y Ginecología, Hospital Torrecárdenas, Paraje Torrecárdenas s/n, 04009, Almeria, Spain

    Ana M. Fernández-Alonso & Gabriel Fiol-Ruiz

  2. Hospital Gineco-Obstétrico Enrique C. Sotomayor, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador

    Peter Chedraui

  3. Departamento de Obstetricia y Ginecología, Hospital Clínico de Zaragoza, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain

    Faustino R. Pérez-López

Authors
  1. Ana M. Fernández-Alonso
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  2. Gabriel Fiol-Ruiz
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  3. Peter Chedraui
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  4. Faustino R. Pérez-López
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Corresponding author

Correspondence to Ana M. Fernández-Alonso.

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Fernández-Alonso, A.M., Fiol-Ruiz, G., Chedraui, P. et al. Lack of correlation between first trimester maternal serum 25-hydroxyvitamin D levels and ultrasound measured crown-rump length and nuchal translucency. Arch Gynecol Obstet 284, 1585–1588 (2011). https://doi.org/10.1007/s00404-011-2071-y

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  • DOI: https://doi.org/10.1007/s00404-011-2071-y

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