Abstract
Objective
To perform systematic review and meta-analysis to evaluate the risk of preeclampsia after chorionic villus sampling (CVS).
Data sources
A systematic search of PubMED and Web of Science from inception through August 2010, and bibliographies of review articles and eligible studies were performed.
Methods of study selection
Six studies reported the risk of preeclampsia after CVS. All of the identified studies were retrospective and included in analysis.
Tabulation, integration, and results
Reporting quality of the identified studies according to quality assessment scale for methodology in retrospective clinical reporting was moderate. Pooling was performed in two strata for control: (1) patients without any invasive prenatal diagnostic procedure served as control group: no significant difference was found in the odds ratio (OR) of preeclampsia (OR 0.79, 95% CI 0.38–1.64), severe preeclampsia (OR 0.49, 95% CI 0.04–5.78), gestational hypertension (OR 0.76, 95% CI 0.46–1.26), all pregnancy-induced hypertensive disorders (OR 0.80, 95% CI 0.46–1.41) between CVS and control groups. (2) Patients with amniocentesis combined with patients without any invasive prenatal diagnostic procedure served as control group: no significant difference was found in the OR of preeclampsia (OR 0.76, 95% CI 0.37–1.53), severe preeclampsia (OR 0.83, 95% CI 0.14–4.85), all pregnancy-induced hypertensive disorders (OR 0.92, 95% CI 0.55–1.53) between CVS and combined control groups.
Conclusion
None of the included studies were randomized prospective trials designed to investigate the effect of CVS on preeclampsia. Accordingly, this review is limited by the heterogeneity, small number and retrospective nature of the available studies. CVS does not seem to increase the risk of preeclampsia or other pregnancy-induced hypertensive disorders. However, randomized prospective trials that are designed to investigate the risk of preeclampsia after CVS are needed to make a definite conclusion.
Similar content being viewed by others
Abbreviations
- CVS:
-
Chorionic villus sampling
- OR:
-
Odds ratio
- CI:
-
Confidence interval
References
Duley L (1992) Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean. Br J Obstet Gynaecol 99(7):547–553
Gupta S, Agarwal A, Sharma RK (2005) The role of placental oxidative stress and lipid peroxidation in preeclampsia. Obstet Gynecol Surv 60(12):807–816
Carty DM, Delles C, Dominiczak AF (2010) Preeclampsia and future maternal health. J Hypertens 28(7):1349–1355
Lyall F (2006) Mechanisms regulating cytotrophoblast invasion in normal pregnancy and pre-eclampsia. Aust N Z J Obstet Gynaecol 46(4):266–273
Farina A, Hasegawa J, Raffaelli S, Ceccarini C, Rapacchia G, Pittalis MC et al (2010) The association between preeclampsia and placental disruption induced by chorionic villous sampling. Prenat Diagn 30(6):571–574
Katiyar R, Kriplani A, Agarwal N, Bhatla N, Kabra M (2007) Detection of fetomaternal hemorrhage following chorionic villus sampling by Kleihauer Betke test and rise in maternal serum alpha feto protein. Prenat Diagn 27(2):139–142
Silver RK, Wilson RD, Philip J, Thom EA, Zachary JM, Mohide P et al (2005) Late first-trimester placental disruption and subsequent gestational hypertension/preeclampsia. Obstet Gynecol 105(3):587–592
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283(15):2008–2012
Rangel SJ, Kelsey J, Colby CE, Anderson J, Moss RL (2003) Development of a quality assessment scale for retrospective clinical studies in pediatric surgery. J Pediatr Surg 38(3):390–396 discussion -6
(2008) Review Manager (RevMan) [Computer program]. Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159–174
Grobman WA, Auger M, Shulman LP, Elias S (2009) The association between chorionic villus sampling and preeclampsia. Prenat Diagn 29(8):800–803
Lindgren P, Cederholm M, Haglund B, Axelsson O (2010) Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia. BJOG 117(11):1422–1425
Odibo AO, Singla A, Gray DL, Dicke JM, Oberle B, Crane J (2010) Is chorionic villus sampling associated with hypertensive disorders of pregnancy? Prenat Diagn 30(1):9–13
Adusumalli J, Han CS, Beckham S, Bartholomew ML, Williams J 3rd (2007) Chorionic villus sampling and risk for hypertensive disorders of pregnancy. Am J Obstet Gynecol 196(6):591e1–591e7 discussion e7
Khalil A, Akolekar R, Pandya P, Syngelaki A, Nicolaides K (2010) Chorionic villus sampling at 11–13 weeks of gestation and hypertensive disorders in pregnancy. Obstet Gynecol 116(2 Pt 1):374–380
Roberts JM, Myatt L, Spong CY, Thom EA, Hauth JC, Leveno KJ et al (2010) Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med 362(14):1282–1291
Philip J, Silver RK, Wilson RD, Thom EA, Zachary JM, Mohide P et al (2004) Late first-trimester invasive prenatal diagnosis: results of an international randomized trial. Obstet Gynecol 103(6):1164–1173
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (2009) Power analysis for meta-analysis
Conflict of interest
The authors declare that there are no conflicts of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Basaran, A., Basaran, M. & Topatan, B. Chorionic villus sampling and the risk of preeclamspia: a systematic review and meta-analysis. Arch Gynecol Obstet 283, 1175–1181 (2011). https://doi.org/10.1007/s00404-011-1840-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-011-1840-y