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Hidradenoma papilliferum of the vulva: case report and review of literature


Hidradenoma papilliferum (HP) is a rare, small, benign, cystic, papillary, slow growing tumor occurring in anogenital region of adult women. The authors describe a case of large, rapidly enlarging HP of vulva in a 25-year-old woman and review the literature available on this rare condition.

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  1. Docimo S, Shon W, Elkowitz DE (2008) Bartholin’s abcess arising within hidradenoma papilliferum of the vulva: a case report. Cases J 1:282

    PubMed  Article  Google Scholar 

  2. Meeker JH, Nenbecker RD, Helwig EB (1962) Hidradenoma papilliferum. Am J Clin Pathol 37:182–195

    PubMed  CAS  Google Scholar 

  3. Handa Y, Yamanaka N, Inagaki H, Tomita Y (2003) Large ulcerated perianal hidradenoma papilliferum in a young female. Dermatol Surg 29(7):790–792

    PubMed  Article  Google Scholar 

  4. Silva AC, Nascimento AG, DaSilva CS, Murta EF, Adad SJ (2005) Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study. Sao Paulo Med J 123:250–252

    PubMed  Google Scholar 

  5. Dewdney S, Kennedy CM, Galask RP (2005) Leiomyosarcoma of the vulva:a case report. J Reprod Med 50:630–632

    PubMed  Google Scholar 

  6. Barre C, Lorenzato M, Bourdat B, Quereux C, Durlach A (2007) Vulvar invasive squamous cell carcinoma and hidradenoma papilliferum. Case report. Gynecol Obstet Fertil 35(9):776–779

    PubMed  Article  CAS  Google Scholar 

  7. Simpson WA, Burke M, Frappell J, Cook MG (1988) Paget’s disease, melanocytic neoplasia and hidradenoma papilliferum of the vulva. Histopathology 12(6):675–679

    PubMed  Article  CAS  Google Scholar 

  8. Nishie W, Sawamura D, Mayuzumi M, Takahashi S, Shimizu H (2004) Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary like glands. J Cutan Pathol 31(8):561–564

    PubMed  Article  Google Scholar 

  9. Wilkinson EJ, Xie D (2004) Benign disorders of the Vulva. In: Kurman RJ (ed) Blaustein’s pathology of the female genital tract, 5th ed edn. Springer, New Delhi, pp 37–98

    Google Scholar 

  10. Vazmitel M, Spagnolo DV, Nemcova J, Michal M, Kazakov DV (2008) Hidradenoma papilliferum with a ductal carcinoma in situ component: case report and review of literature. Am J Dermatopathol 30(4):392–394

    PubMed  Article  Google Scholar 

  11. Kazakov DV, Mikyskona I, Kutzner H, Simpson RH, Hes O, Mukensnabl P et al (2005) Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papilloma virus. Am J Dermatopathol 27(2):102–110

    PubMed  Article  Google Scholar 

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Correspondence to Nirmala Duhan.

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Duhan, N., Kalra, R., Singh, S. et al. Hidradenoma papilliferum of the vulva: case report and review of literature. Arch Gynecol Obstet 284, 1015–1017 (2011).

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  • Hidradenoma papilliferum
  • Vulva
  • Tumor