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Cervical cytology of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H): histological results and recurrence after a loop electrosurgical excision procedure

Archives of Gynecology and Obstetrics volume 284, pages 965–971 (2011)Cite this article

Abstract

Objectives

To evaluate the histology of the loop electrosurgical excision procedure (LEEP) surgical tissues of patients with ASC-H and post-LEEP recurrence.

Methods

Medical records of patients with ASC-H treated with LEEP between January 2004 and March 2008 in the town of União da Vitória, Paraná, seat of the Sixth Public Health Region of Paraná (CISVALI), were evaluated. The LEEP was carried out solely for ASC-H immediately after colposcopy, but without a histological diagnosis.

Results

Most patients were less than 40 years old (71.1%), with the largest group 20–39 years old (p < 0.0001). Twenty-eight patients (73.3%) showed histological lesions. Cervical intraepithelial neoplasias (CIN) I was present in 7 (18.4%), CIN II and CIN III in 9 (23.7%) each, microinvasive squamous cell carcinoma (SCMCA) in 2 (5.3%), and SCMCA plus in situ adenocarcinoma in 1 (2.2%). In 32 patients (84.2%), there was no involvement of the margins, including 100% with no dysplasia histology and CIN I, 80.0% of those with CIN II, and 88.9% of those with CIN III. Two patients (5.3%) had endocervical involvement, all of them with CIN II. Four patients (10.5%) had ectocervical and endocervical involvement, one of them with CIN III, and three of them with carcinomas. All patients with follow-up (+) were ASC-US, with no patients with dysplasia or CIN I.

Conclusions

A very high portion of the women with ASC-H had lesions on post-LEEP histological examination, principally CIN II and III. These data show the benefits of treatment for ASC-H by LEEP immediately after colposcopy but without any previous histology.

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We declare that we have no conflict of interest.

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Affiliations

  1. Division of Clinical Cytology, Clinical Analyses Department, Teaching and Research Laboratory of Clinical Analysis, State University of Maringá, Maringá, Paraná, Brazil

    P. R. B. Nogara & M. E. L. Consolaro

  2. Sixth Region of Public Health of Paraná (CISVALI), Uniao da Vitoria, Paraná, Brazil

    L. A. R. Manfroni

  3. Departamento de Análises Clínicas, DAC, Universidade Estadual de Maringá, Av: Colombo, 5790, Maringá, Paraná, 87020-900, Brazil

    M. E. L. Consolaro

Authors
  1. P. R. B. Nogara
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Correspondence to M. E. L. Consolaro.

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Nogara, P.R.B., Manfroni, L.A.R. & Consolaro, M.E.L. Cervical cytology of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H): histological results and recurrence after a loop electrosurgical excision procedure. Arch Gynecol Obstet 284, 965–971 (2011). https://doi.org/10.1007/s00404-010-1731-7

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Keywords

  • Atypical squamous cell
  • ASC-H
  • LEEP
  • Histology
  • Recurrence