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Secondary malignant fibrous histiocytoma of thigh with surface ulceration following radiotherapy for carcinoma cervix

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Abstract

Introduction

Radiotherapy is known to cause rarely various malignancies including leukemia, sarcoma, and thyroid and lung carcinoma. Post-radiation sarcomas account for 0.5–5.5% of all sarcomas; and include extra skeletal osteosarcoma, fibrosarcoma leiomyosarcoma, and malignant fibrous histiocytoma. Reports on post radiotherapy malignant fibrous histiocytoma in cervical cancer patients are rare.

Case report

We present a case of 45-years-old female diagnosed with squamous cell carcinoma of the uterine cervix stage IIB; she underwent a radical hysterectomy with pelvic lymphadenectomy and postoperative radiotherapy and chemotherapy. Five years later, she presented with ulcerated nodular masses in right and left medial aspect of thigh. Cytological and histological diagnosis of the masses was malignant fibrous histiocytoma which was further confirmed by immunohistochemistry.

Conclusion

Post-irradiation sarcoma must be considered in patients of carcinoma cervix treated with radiotherapy, when soft tissue mass is seen in the previously irradiated area. It should be differentiated from metastasis from primary tumor with the help of appropriate markers as it has a grave prognosis.

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Authors and Affiliations

  1. Department of Pathology, Maulana Azad Medical College and Associated Hospitals, New Delhi, 110003, India

    Prerna Arora, Rachna Wadhwa & Nita Khurana

  2. Department of Pathology, Maulana Azad Medical College and Associated Hospitals, 20/59, Lodhi Colony, New Delhi, 110003, India

    Shyama Jain

  3. Department of Surgery, Maulana Azad Medical College and Associated Hospitals, New Delhi, India

    N. S. Hadke

Authors
  1. Prerna Arora
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  2. Rachna Wadhwa
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  3. Nita Khurana
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  4. Shyama Jain
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  5. N. S. Hadke
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Corresponding author

Correspondence to Shyama Jain.

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Arora, P., Wadhwa, R., Khurana, N. et al. Secondary malignant fibrous histiocytoma of thigh with surface ulceration following radiotherapy for carcinoma cervix. Arch Gynecol Obstet 283 (Suppl 1), 79–82 (2011). https://doi.org/10.1007/s00404-010-1699-3

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  • DOI: https://doi.org/10.1007/s00404-010-1699-3

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