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Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes

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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Secretory carcinoma is a rare form of breast cancer most frequently encountered in children or young adults. Several cases have been described in adults with increased aggressiveness and a risk of metastases.

Case report

We report here, in a 30-year-old woman, a case of local relapse and lymph node metastases occurring 16 years after the initial diagnosis of secretory carcinoma.

Conclusion

We present the clinical, radiological and pathological findings that led to the diagnosis.

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References

  1. Nogales F, Tavassoli FA (2003) Pathology and genetics of tumors of the breast and female genital organs. IARC Press, Lyon

    Google Scholar 

  2. McDivitt RW, Stewart FW (1966) Breast carcinoma in children. JAMA 195(5):388–390

    Article  PubMed  CAS  Google Scholar 

  3. Vieni S, Cabibi D, Cipolla C, Fricano S, Graceffa G, Latteri MA (2006) Secretory breast carcinoma with metastatic sentinel lymph node. World J Surg Oncol 4:88

    Article  PubMed  Google Scholar 

  4. Jacquemier J (2009) Diagnostic pitfalls in mammary pathology. Case 5. Secretory carcinoma. Ann Pathol 29(3):211–215

    Article  PubMed  Google Scholar 

  5. Lannon CL, Sorensen PH (2005) ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol 15(3):215–223

    Article  PubMed  CAS  Google Scholar 

  6. Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI et al (2007) ETV6- NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell 12(6):542–558

    Article  PubMed  CAS  Google Scholar 

  7. Makretsov N, He M, Hayes M, Chia S, Horsman DE, Sorensen PH et al (2004) A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma. Genes Chromosomes Cancer 40(2):152–157

    Article  PubMed  CAS  Google Scholar 

  8. Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA et al (2002) Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2(5):367–376

    Article  PubMed  CAS  Google Scholar 

  9. Lae M, Freneaux P, Sastre-Garau X, Chouchane O, Sigal-Zafrani B, Vincent-Salomon A (2009) Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basallike carcinoma spectrum. Mod Pathol 22(2):291–298

    Article  PubMed  CAS  Google Scholar 

  10. Fadare O, Tavassoli FA (2008) Clinical and pathologic aspects of basal-like breast cancers. Nat Clin Pract Oncol 5(3):149–159

    Article  PubMed  Google Scholar 

  11. Krausz T, Jenkins D, Grontoft O, Pollock DJ, Azzopardi JG (1989) Secretory carcinoma of the breast in adults: emphasis on late recurrence and metastasis. Histopathology 14(1):25–36

    Article  PubMed  CAS  Google Scholar 

  12. Iglesias B, Monteagudo B, Rouco JS, Anton I (2009) Secretory breast carcinoma in a 63-year-old man. J Cutan Pathol 36(Suppl 1):86–88

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We thank Philip Bastable for his help in revising the manuscript.

Conflict of interest

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Oncological Surgery, Georges François Leclerc Anticancer Centre, 1, rue du Professeur Marion, 21000, Dijon, France

    Hervé Tixier, Anne Picard, Catherine Loustalot & Jean Cuisenier

  2. Faculty of Medicine, INSERM UMR 866, 7 boulevard Jeanne d’Arc, Dijon, France

    Hervé Tixier

  3. Department of Pathology, Georges François Leclerc Anticancer Centre, 1, rue du Professeur Marion, 21000, Dijon, France

    Laurent Arnould

  4. Department of Medical Oncology, Georges François Leclerc Anticancer Centre, 1, rue du Professeur Marion, 21000, Dijon, France

    Séverine Guiu & Bruno Coudert

  5. Cabinet de Pathologie, 33, chemin des Tilleroyes, 25006, Besançon, France

    Olivier Depret

Authors
  1. Hervé Tixier
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  2. Anne Picard
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  3. Séverine Guiu
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  4. Bruno Coudert
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  5. Catherine Loustalot
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  6. Olivier Depret
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  7. Laurent Arnould
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  8. Jean Cuisenier
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Corresponding author

Correspondence to Hervé Tixier.

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Tixier, H., Picard, A., Guiu, S. et al. Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. Arch Gynecol Obstet 283 (Suppl 1), 77–78 (2011). https://doi.org/10.1007/s00404-010-1669-9

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  • DOI: https://doi.org/10.1007/s00404-010-1669-9

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