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Archives of Gynecology and Obstetrics

, Volume 284, Issue 2, pp 313–317 | Cite as

Influence of pregnancy and smoking on brachial artery flow-mediated dilation values and time until maximum response

  • Luis G. C. Nicolau
  • Wellington P. MartinsEmail author
  • Francisco M. P. Gallarreta
  • Jailson C. Lima
  • Francisco Mauad Filho
Materno-fetal Medicine

Abstract

Purpose

To evaluate the effect of pregnancy and smoking on endothelial function using brachial artery flow-mediated dilation (FMD) and to determine the time necessary until the occurrence of maximum brachial artery dilation after stimulus.

Methods

This study was an observational study evaluating 133 women, who were grouped as follows: non-smoking pregnant women (N = 47), smoking pregnant women (N = 33), non-smoking women (N = 34), and smoking pregnant women (N = 19). The diameter of the brachial artery was measured at baseline and at 30, 60, 90 and 120 s after stimulus. The relative change of brachial artery was determined for each of these four moments. FMD measured at 60 s after stimulus was compared between the groups.

Results

The maximum FMD was observed at 60 s after cuff release in all groups. FMD was greater among non-smoking pregnant women compared to smoking pregnant women (11.50 ± 5.77 vs. 8.74 ± 4.83; p = 0.03) and also between non-smoking non-pregnant women compared to smoking non-pregnant women (10.52 ± 4.76 vs. 7.21 ± 5.57; p = 0.03).

Conclusions

Maximum FMD was observed approximately 60 s after stimulus in all groups regardless of smoking and pregnancy status. The smoking habit seems to lead to endothelial dysfunction both in pregnant and non-pregnant women, as demonstrated by the lower FMD in smokers.

Keywords

Ultrasonography Endothelium Pregnancy Smoking 

Notes

Conflict of interest

We declare that we have no conflict of interest.

References

  1. 1.
    Williams JK, Anthony MS, Honore EK, Herrington DM, Morgan TM, Register TC, Clarkson TB (1995) Regression of atherosclerosis in female monkeys. Arterioscler Thromb Vasc Biol 15:827–836PubMedCrossRefGoogle Scholar
  2. 2.
    Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Luscher TF (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91:1314–1319PubMedGoogle Scholar
  3. 3.
    Okahara K, Sun B, Kawasaki T, Monden M, Kambayashi J (1998) Expression of platelet-activating factor receptor transcript-2 is induced by shear stress in HUVEC. Prostaglandins Other Lipid Mediat 55:323–329PubMedCrossRefGoogle Scholar
  4. 4.
    Dorup I, Skajaa K, Sorensen KE (1999) Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation. Am J Physiol 276:H821–H825PubMedGoogle Scholar
  5. 5.
    Nakamura MU, Alexandre SM, Kuhn dos Santos JF, de Souza E, Sass N, Auritscher Beck AP, Trayna E, Andrade CM, Barroso T, Kulay Junior L (2004) Obstetric and perinatal effects of active and/or passive smoking during pregnancy. Sao Paulo Med J 122:94–98PubMedCrossRefGoogle Scholar
  6. 6.
    Adamopoulos D, van de Borne P, Argacha JF (2008) New insights into the sympathetic, endothelial and coronary effects of nicotine. Clin Exp Pharmacol Physiol 35:458–463PubMedCrossRefGoogle Scholar
  7. 7.
    Erhardt L (2009) Cigarette smoking: an undertreated risk factor for cardiovascular disease. Atherosclerosis 205:23–32PubMedCrossRefGoogle Scholar
  8. 8.
    Donald AE, Charakida M, Cole TJ, Friberg P, Chowienczyk PJ, Millasseau SC, Deanfield JE, Halcox JP (2006) Non-invasive assessment of endothelial function: which technique? J Am Coll Cardiol 48:1846–1850PubMedCrossRefGoogle Scholar
  9. 9.
    Joannides R, Bellien J, Thuillez C (2006) Clinical methods for the evaluation of endothelial function–a focus on resistance arteries. Fundam Clin Pharmacol 20:311–320PubMedCrossRefGoogle Scholar
  10. 10.
    Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39:257–265PubMedCrossRefGoogle Scholar
  11. 11.
    Craiem D, Chironi G, Simon A, Levenson J (2008) New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction. Am J Ther 15:340–344PubMedCrossRefGoogle Scholar
  12. 12.
    Martins WP, Nastri CO, Ferriani RA, Filho FM (2008) Brachial artery pulsatility index change 1 min after 5-min forearm compression: comparison with flow-mediated dilatation. J Ultrasound Med 27:693–699PubMedGoogle Scholar
  13. 13.
    Soares GM, Vieira CS, Martins WP, Franceschini SA, dos Reis RM, Silva de Sa MF, Ferriani RA (2009) Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? Clin Endocrinol (Oxf) 71:406–411CrossRefGoogle Scholar
  14. 14.
    Takase B, Goto T, Hamabe A, Uehata A, Kuroda K, Satomura K, Ohsuzu F, Kurita A (2003) Flow-mediated dilation in brachial artery in the second half of pregnancy and prediction of pre-eclampsia. J Hum Hypertens 17:697–704PubMedCrossRefGoogle Scholar
  15. 15.
    Kallio K, Jokinen E, Raitakari OT, Hamalainen M, Siltala M, Volanen I, Kaitosaari T, Viikari J, Ronnemaa T, Simell O (2007) Tobacco smoke exposure is associated with attenuated endothelial function in 11-year-old healthy children. Circulation 115:3205–3212PubMedCrossRefGoogle Scholar
  16. 16.
    Martins Wde P, Soares GM, Vieira CS, dos Reis RM, de Sa MF, Ferriani RA (2009) Cardiovascular risk markers in polycystic ovary syndrome in women with and without insulin resistance. Rev Bras Ginecol Obstet 31:111–116PubMedCrossRefGoogle Scholar
  17. 17.
    Nastri CO, Martins WP, Ferriani RA, Filho FM, dos Reis FJ (2008) Sonographic evaluation of endothelial function in letrozole and tamoxifen users. Maturitas 61:340–344PubMedCrossRefGoogle Scholar
  18. 18.
    Hashimoto M, Miyamoto Y, Matsuda Y, Akita H (2003) New methods to evaluate endothelial function: non-invasive method of evaluating endothelial function in humans. J Pharmacol Sci 93:405–408PubMedCrossRefGoogle Scholar
  19. 19.
    Quinton AE, Cook CM, Peek MJ (2007) A longitudinal study using ultrasound to assess flow-mediated dilatation in normal human pregnancy. Hypertens Pregnancy 26:273–281PubMedCrossRefGoogle Scholar
  20. 20.
    Savvidou MD, Kametas NA, Donald AE, Nicolaides KH (2000) Non-invasive assessment of endothelial function in normal pregnancy. Ultrasound Obstet Gynecol 15:502–507PubMedCrossRefGoogle Scholar
  21. 21.
    Lizarelli PM, Martins WP, Vieira CS, Soares GM, Franceschini SA, Ferriani RA, Patta MC (2009) Both a combined oral contraceptive and depot medroxyprogesterone acetate impair endothelial function in young women. Contraception 79:35–40PubMedCrossRefGoogle Scholar
  22. 22.
    Sierra-Laguado J, Garcia RG, Lopez-Jaramillo P (2006) Flow-mediated dilatation of the brachial artery in pregnancy. Int J Gynaecol Obstet 93:60–61PubMedCrossRefGoogle Scholar
  23. 23.
    Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, Deanfield JE (1993) Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 88:2149–2155PubMedGoogle Scholar
  24. 24.
    Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A, Deanfield JE (1996) Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med 334:150–154PubMedCrossRefGoogle Scholar
  25. 25.
    Holay MP, Paunikar NP, Joshi PP, Sahasrabhojney VS, Tankhiwale SR (2004) Effect of passive smoking on endothelial function in: healthy adults. J Assoc Physicians India 52:114–117PubMedGoogle Scholar
  26. 26.
    Rosemberg J (2005) Nicotina—Droga Universal. Instituto Nacional do Câncer—INCA, Rio de Janeiro. http://www.inca.gov.br/tabagismo/publicacoes/nicotina.pdf
  27. 27.
    Vaz JO (2000) Alterações Hemodinâmicas durante a gravidez. In: de Oliveris HC, Benzecry R, Lemgruber I (eds) Tratado de Obstetrícia FEBRASGO. Revinter, Rio de Janeiro, pp 62–63Google Scholar
  28. 28.
    West RJ, Russell MA (1987) Cardiovascular and subjective effects of smoking before and after 24 h of abstinence from cigarettes. Psychopharmacology (Berl) 92:118–121CrossRefGoogle Scholar
  29. 29.
    Benowitz NL (1997) The role of nicotine in smoking-related cardiovascular disease. Prev Med 26:412–417PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Luis G. C. Nicolau
    • 1
    • 2
  • Wellington P. Martins
    • 1
    • 2
    Email author
  • Francisco M. P. Gallarreta
    • 1
    • 2
  • Jailson C. Lima
    • 1
    • 2
  • Francisco Mauad Filho
    • 1
    • 2
  1. 1.Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP)Ribeirão PrêtoBrazil
  2. 2.Departamento de Ginecologia e ObstetríciaFaculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)Ribeirão PrêtoBrazil

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