Archives of Gynecology and Obstetrics

, Volume 284, Issue 2, pp 327–329 | Cite as

Maternal and fetal leptin and ghrelin levels: relationship with fetal growth

  • Filiz Saylan
  • Gülengül Köken
  • Emine CosarEmail author
  • Tülay Köken
  • Arif Saylan
  • Dağıstan Tolga Arıöz
  • Figen Şahin
  • Reşit Köken
  • Mehmet Yılmazer
Materno-fetal medicine



In our study, we investigated the influence of plasma levels ghrelin, leptin and other metabolic hormones (ILGF-1 and ILGF-2) in pregnants in regulating fetal body weight and mode of delivery.


A total of 36 appropriately healthy pregnants 19–36-year-old were involved in the study. Demographic chracteristics, serum ghrelin, leptin, IGF-1 and IGF-2 levels of the pregnants were studied.


Plasma ghrelin and leptin levels did not differ significantly among trimesters and delivery, in contrast to IGF-I and IGF-II concentrations were significantly higher in the first half of the pregnancy (P < 0.05). Serum leptin was significantly associated with mode of delivery (r = 0.231; P = 0.008), BMI (r = 0.462; P = 0.004).


Metabolic factors are associated with fetal growth, but in AGA babies, there were no differences between any parameter and clinical factor.


Ghrelin Leptin Birthweight 


Conflict of interest



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Filiz Saylan
    • 1
  • Gülengül Köken
    • 2
  • Emine Cosar
    • 3
    Email author
  • Tülay Köken
    • 2
  • Arif Saylan
    • 1
  • Dağıstan Tolga Arıöz
    • 2
  • Figen Şahin
    • 4
  • Reşit Köken
    • 5
  • Mehmet Yılmazer
    • 2
  1. 1.Erzincan Government HospitalErzincanTurkey
  2. 2.Department of Obstetrics and Gynecology, Faculty of MedicineAfyon Kocatepe UniversityAfyonTurkey
  3. 3.Department of Obstetrics and Gynecology, Faculty of MedicineÇanakkale Onsekiz Mart UniversityÇanakkaleTurkey
  4. 4.Department of Obstetrics and Gynecology, Faculty of MedicineRize UniversityRizeTurkey
  5. 5.Department of Pediatrics, Faculty of MedicineAkdeniz UniversityAntalyaTurkey

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