Archives of Gynecology and Obstetrics

, Volume 284, Issue 2, pp 303–306 | Cite as

B cell acute lymphocytic leukemia in pregnancy

  • Justin Bottsford-Miller
  • Sina HaeriEmail author
  • Arthur M. Baker
  • Jeremiah Boles
  • Mark Brown
Materno-fetal Medicine


Acute lymphocytic leukemia (ALL) is a rare occurrence in pregnancy and can be rapidly fatal if left untreated. The need for immediate treatment of ALL, coupled with the maternal–fetal risks from the chemotherapy regimen render a therapeutic dilemma in pregnant women with ALL. We report a case of ALL diagnosed in the 24th week of pregnancy to outline our management strategy, to demonstrate the feasibility of treatment with multi-agent chemotherapy, and to provide a review of the literature.


Acute lymphocytic leukemia ALL B-cell Pregnancy Cancer Chemotherapy Placenta Metastasis 


Conflict of interest

None of the authors must have a financial relationship or conflict of interest to report.


  1. 1.
    Matsouka C, Marinopoulos S, Barbaroussi D, Antsaklis A (2008) Acute lymphoblastic leukemia during gestation. Med Oncol 25(2):190–193 (epub ahead 27 Nov 2007)PubMedCrossRefGoogle Scholar
  2. 2.
    Hansen WF, Fretz P, Hunter SK, Yankowitz J (2001) Leukemia in pregnancy and fetal response to multiagent chemotherapy. Obstet Gynecol 97(5 Pt 2):809–812PubMedCrossRefGoogle Scholar
  3. 3.
    Ali R, Ozkalemkas F, Kimya Y, Koksal N, Ozkan H, Ozkocaman V, Hoyrazli A, Cetinkaya M, Tunali A (2009) Acute leukemia and pregnancy. Leuk Res 33(3):e26–e28 (epub 15 Aug 2008)PubMedCrossRefGoogle Scholar
  4. 4.
    Chelghoum Y, Vey N, Raffoux E, Huguet F, Pigneux A, Witz B, Pautas C, de Botton S, Guyotat D, Lioure B, Fegueux N, Garban F, Saad H, Thomas X (2005) Acute leukemia during pregnancy: a report on 37 patients and a review of the literature. Cancer 104(1):110–117PubMedCrossRefGoogle Scholar
  5. 5.
    Cardonick E, Iacobucci A (2004) Use of chemotherapy during human pregnancy. Lancet Oncol 5(5):283–291PubMedCrossRefGoogle Scholar
  6. 6.
    Boissel N, Auclerc MF, Lhéritier V, Perel Y, Thomas X, Leblanc T, Rousselot P, Cayuela JM, Gabert J, Fegueux N, Piguet C, Huguet-Rigal F, Berthou C, Boiron JM, Pautas C, Michel G, Fière D, Leverger G, Dombret H, Baruchel A (2003) Should adolescents with ALL be treated as old children or young adults? Comparison of the Frence FRALLE-93 and LALA-94 trials. J Clin Oncol 21(5):774–780 (epub ahead 1 Mar 2003)PubMedCrossRefGoogle Scholar
  7. 7.
    Stock W, La M, Sanford B, Bloomfield CD, Vardiman JW, Gaynon P, Larson RA, Nachman J, Children’s Cancer Group, Cancer and Leukemia Group B studies (2008) What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children’s Cancer Group and Cancer and Leukemia Group B studies. Blood 112(5):1646–1654 (epub ahead 23 May 2008)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Justin Bottsford-Miller
    • 1
  • Sina Haeri
    • 1
    Email author
  • Arthur M. Baker
    • 1
  • Jeremiah Boles
    • 2
  • Mark Brown
    • 2
  1. 1.Division of Maternal-Fetal Medicine, Department of Obstetrics and GynecologyUniversity of North Carolina at Chapel Hill School of MedicineChapel HillUSA
  2. 2.Division of Hematology-Oncology, Department of Internal MedicineUniversity of North Carolina at Chapel Hill School of MedicineChapel HillUSA

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