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Archives of Gynecology and Obstetrics

, Volume 284, Issue 2, pp 453–457 | Cite as

High squamous intraepithelial lesion and cancer of lower genital tract in women with anogenital warts

  • Miodrag MilojkovicEmail author
  • Dimitrije Milojkovic
  • Mico Rosso
  • Bojana Vujic Vakanjac
Gynecologic Oncology

Abstract

Purpose

The aim of this paper was to determine the incidence of high-grade squamous intraepithelial lesion (HSIL) and cancer of lower genital tract in patients with anogenital warts and their treatment.

Methods

Between 1 September 1988 and 30 June 1994, 221 consecutive women with anogenital warts were prospectively examined in the colposcopy outpatient clinic. In 2004, the same group of patients was re-examined.

Results

There were abnormal cytological findings in 111 (50.2%) patients; 31 patients (14.0%) had HSIL, and 6 of them (2.7%) had cancer. There were abnormal colposcopic findings in 152 (68.8%) women; 78 women (35.3%) had abnormal histological findings. In the histological findings, HSIL was found in 41 (18.5%) women and cancer in 6 (2.7%).

Conclusion

In spite of the fact that anogenital warts are caused by HPV types of low oncogenic risk (6/11), there is an increased incidence of HSIL and cancer in these women. Therefore, women with anogenital warts belong to an increased risk group regarding the cancer of lower genital tract, especially if they are associated with HPV types of a high oncogenic risk.

Keywords

Anogenital warts High squamous intraepithelial lesion Genital cancer 

Notes

Conflict of interest

None.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Miodrag Milojkovic
    • 1
    Email author
  • Dimitrije Milojkovic
    • 1
  • Mico Rosso
    • 1
  • Bojana Vujic Vakanjac
    • 1
  1. 1.Department of Gynecology and ObstetricsClinical Hospital OsijekOsijekCroatia

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