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Archives of Gynecology and Obstetrics

, Volume 284, Issue 2, pp 281–285 | Cite as

Pregnancy outcome in systemic lupus erythematosus: Asia’s largest single centre study

  • Neelam Aggarwal
  • Ainharan RaveendranEmail author
  • Vanita Suri
  • Seema Chopra
  • Pooja Sikka
  • Aman Sharma
Materno-fetal Medicine

Abstract

Aim

To evaluate pregnancy outcome in women with systemic lupus erythematosus (SLE).

Methods

A total of 71 pregnancies in 35 women with SLE were evaluated for maternal and perinatal outcomes in a tertiary centre of Northern India. Thirty-five pregnancies were evaluated prospectively while details of previous 36 pregnancies in the same women were studied retrospectively.

Results

The Mean age of pregnant women with SLE was 26.89 ± 2.7 years and 14.57% were nulliparous. The presenting event was arthritis in 60% of the patients; others presented with febrile illness, renal manifestation and cutaneous manifestation. One woman was lupus anticoagulant positive. All women conceived while on disease quiescence period and were continued on the same pre-pregnancy dose of pharmacological agents. Hypertensive disorders of pregnancy were seen in 28.5% while chronic hypertension was seen in 5.6%. The incidence of abortion, preterm deliveries and perinatal loss was 33.8, 29.57 and 12.67%, respectively. Vaginal delivery rate was 47.88 and 18.3% underwent caesarean section. There was no case of neonatal lupus and none had disease flare-up in the postpartum period.

Conclusion

A better pregnancy outcome can be expected if clinical remission is achieved and disease activity is adequately controlled prior to pregnancy.

Keywords

Arthritis Azathioprine Lupus pregnancy Neonatal lupus Systemic lupus erythematosus 

Notes

Conflict of interest

None.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Neelam Aggarwal
    • 1
  • Ainharan Raveendran
    • 1
    Email author
  • Vanita Suri
    • 1
  • Seema Chopra
    • 1
  • Pooja Sikka
    • 1
  • Aman Sharma
    • 2
  1. 1.Department of Obstetrics and GynaecologyPost Graduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Rheumatology Wing, Department of Internal MedicinePost Graduate Institute of Medical Education and ResearchChandigarhIndia

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