Comments on the letter “Fertility preservation and GnRHa for chemotherapy: debate”
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Thank you very much for the critical comments. Any critical comment on the use of GnRH analogs (GnRHa) to protect fertility during chemotherapy is of great value in further discussions of the controversial data and the controversial attitudes of endocrinologists and ocologists.
We fully agree with the authors of the letter that several studies support the efficacy of GnRHa to protect the ovaries, which we have also demonstrated in a review summarizing nine studies on the use of GnRHa . We also agree with the authors that the efficacy of other fertility preserving techniques such as cryopreservation and transplantation of ovarian tissue need further evaluation and that their safety has still not absolutely been proven, as stated in our recent review about cryopreservation of ovarian tissue . Finally, we are fully aware that GnRHa provide several additional advantages during chemotherapy such as reducing the risk of thrombocytopenia-associated menorrhagia.
However, we do not agree...
KeywordsBreast Cancer Patient Ovarian Tissue Ovarian Stimulation Fertility Preservation GnRH Analog
Conflict of interest statement
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