Smoking and AMH levels in women with normal reproductive history
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To investigate the effect of age and smoking on the AMH levels in normal cycling healthy women with normal reproductive history.
Materials and methods
In 137 women, blood samples were taken on day 3 of a spontaneous cycle. Serum FSH, LH, E2, progesterone and AMH were measured in all blood samples. For the statistical analysis of the data, t test, Pearson’s correlation and linear regression analysis were performed.
Of 137 women (43%), 59 were smokers. Age was positively correlated with serum FSH and LH levels (r = 0.584, P < 0.001 and r = 0.330, P < 0.001, respectively) and negatively correlated with serum AMH levels (r = −0.882, P < 0.001). There were no significant differences in FSH, LH, E2, progesterone and AMH levels between smokers and non-smokers. Multiple stepwise linear regression analysis showed that in both smokers and non-smokers, age was the most significant determinant of AMH levels (r = −0.889, P < 0.001 and r = −0.944, P < 0.001, respectively), while smoking was not related to AMH levels.
Aging significantly decreases AMH levels in women with normal cycles and normal reproductive history, while smoking does not seem to have significant effects on AMH levels.
KeywordsFSH AMH Age Smoking Premenopausal women
Conflict of interest statement
The authors declare that they have no conflict of interest.
- 11.Nardo LG, Christodoulou D, Gould D, Roberts SA, Fitzgerald CT, Laing I (2007) Anti-Müllerian hormone levels and antral follicle count in women enrolled in in vitro fertilization cycles: relationship to lifestyle factors, chronological age and reproductive history. Gynecol Endocrinol 23:486–493CrossRefPubMedGoogle Scholar
- 16.Santoro N, Lasley B, McConnell D, Allsworth J, Crawford S, Gold EB, Finkelstein JS, Greendale GA, Kelsey J, Korenman S, Luborsky JL, Matthews K, Midgley R, Powell L, Sabatine J, Schocken M, Sowers MF, Weiss G (2004) Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: the Study of Women’s Health Across the Nation (SWAN) Daily Hormone Study. J Clin Endocrinol Metab 89:2622–2631CrossRefPubMedGoogle Scholar
- 19.Barbieri RL, McShane PM, Ryan KJ (1996) Constituents of cigarette smoke inhibit granulosa cell aromatase. Fertil Steril 46:232–236Google Scholar
- 28.La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio AC, Stabile G, Volpe A (2009) Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update 16:113–130Google Scholar
- 29.Baarends WM, Uilenbroek JT, Kramer P, Hoogerbrugge JW, van Leeuwen EC, Themmen AP, Grootegoed JA (1995) Anti-Müllerian hormone and anti-Müllerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle and gonadotropin-induced follicle growth. Endocrinology 136:4951–4962CrossRefPubMedGoogle Scholar