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A comparative study on the outcomes of in vitro fertilization between women with polycystic ovary syndrome and those with sonographic polycystic ovary-only in GnRH antagonist cycles

  • Reproductive Medicine
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Abstract

Purpose

This study was performed to compare the outcomes of controlled ovarian stimulation (COH) and IVF between women with PCOS and those with sonographic PCO-only in GnRH antagonist cycles.

Methods

This was a retrospective study of women with PCOS (n = 42) and those with sonographic PCO-only (n = 54) undergoing IVF. Responses to COH, adverse events such as severe ovarian hyperstimulation syndrome (OHSS), embryological and pregnancy outcomes were compared between the two groups using GnRH antagonist cycles and between GnRH agonist and antagonist protocols in the two groups, respectively.

Results

There were no differences in the duration of stimulation, dose of gonadotropins used, E2 level on hCG day, numbers of retrieved oocytes, and incidence of sever OHSS between PCOS and sonographic PCO-only groups, which was also observed both in GnRH agonist and antagonist subgroups. Pregnancy rates between PCOS and sonographic PCO-only groups in GnRH agonist (21.7 vs. 34.4%, P = 0.238) and antagonist (26.3 vs 22.7%, P = 0.537) subgroups did not differ. In regard to COH regimen, GnRH agonist long protocols showed higher responses than antagonist protocols both in PCOS group [number of retrieved oocytes (13.2 ± 5.8 vs. 8.2 ± 3.2, P < 0.001)] and sonographic PCO-only group [number of retrieved oocytes (13.7 ± 5.2 vs. 9.2 ± 6.7, P = 0.008); E2 level on hCG day (3,005.1 ± 1,317.1 vs. 1,525.9 ± 738.6 pg/mL, P < 0.001)].

Conclusions

Women with PCOS and sonographic PCO-only may have similar outcome during COH cycle for IVF.

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Acknowledgments

The authors would like to express our deepest gratitude to Sun Kyung Oh, Hee Sun Kim, Moon Ju Kang, Sung Ah Kim and Jun Ho Ku for their laboratory and statistical support of this study. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (01-PJ10-PG6-01GN13-0002).

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Correspondence to Seung-Yup Ku.

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Kim, Y.J., Ku, SY., Jee, B.C. et al. A comparative study on the outcomes of in vitro fertilization between women with polycystic ovary syndrome and those with sonographic polycystic ovary-only in GnRH antagonist cycles. Arch Gynecol Obstet 282, 199–205 (2010). https://doi.org/10.1007/s00404-010-1401-9

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  • DOI: https://doi.org/10.1007/s00404-010-1401-9

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