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Is increased maternal endotelin-1 concentration associated with neonatal asphyxia and preterm delivery in intrahepatic cholestasis of pregnancy?

  • Materno-fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objectives

To evaluate plasma endothelin-1 (ET-1) and fetuin-A concentrations in women with intrahepatic cholestasis of pregnancy (ICP) and to determine whether there is any association between these parameters and fetal asphyxia.

Methods

We carried out a prospective case–control study consisting of 32 women with ICP at third trimester of pregnancy and 32 pregnant women without ICP. Blood samples from maternal peripheral venous circulation were collected and ET-1 and fetuin-A levels were determined from the plasma samples. Pulse-wave Doppler and Apgar scores were also recorded.

Results

ET-1 concentrations were significantly higher in ICP patients. No difference was observed in fetuin-A levels between the two groups. Six newborns were declared as asphyctic (APGAR score at the 5 min <7). Maternal ET-1 levels did not correlate with the APGAR score at 5 min, total bile acid (TBA) and umbilical artery systolic/diastolic ratio with ICP patients. TBA levels were positively correlated with umbilical artery systolic/diastolic ratio negatively correlated with APGAR score at the 1′ and 5′-Apgar score in all subjects. Plasma ET-1 concentration was higher in the preterm neonates of mothers with ICP compared with normal term neonates of mothers.

Conclusions

Although these data did not show evidence that maternal ET-1 would be associated with fetal distress, we can speculate that maternal ET-1 may be playing a role in the underlying pathology regarding microvascular dysfunction especially in the preterm neonates of mothers with ICP. Elevated TBA levels may increase the risk of asphyxia whereas fetuin-a (as an anti-inflammation marker) does not seem to have effect in women with ICP.

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Authors and Affiliations

  1. Izmir Aegean Obstetrics and Gynecology Teaching Hospital, Izmir, Turkey

    Ayse Gul Kebapcilar, Cuneyt Eftal Taner, Gulcin Sahin & Sevki Goksun Gokulu

  2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Bozyaka Training and Research Hospital, Izmir, Turkey

    Levent Kebapcilar

  3. Department of Biochemistry, Bozyaka Training and Research Hospital, Izmir, Turkey

    Giray Bozkaya

Authors
  1. Ayse Gul Kebapcilar
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  2. Levent Kebapcilar
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  3. Cuneyt Eftal Taner
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  4. Giray Bozkaya
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  5. Gulcin Sahin
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  6. Sevki Goksun Gokulu
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Correspondence to Levent Kebapcilar.

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Kebapcilar, A.G., Kebapcilar, L., Taner, C.E. et al. Is increased maternal endotelin-1 concentration associated with neonatal asphyxia and preterm delivery in intrahepatic cholestasis of pregnancy?. Arch Gynecol Obstet 282, 617–621 (2010). https://doi.org/10.1007/s00404-009-1261-3

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  • DOI: https://doi.org/10.1007/s00404-009-1261-3

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