Skip to main content
Log in

The effect of ovarian cyst aspiration on IVF treatment with GnRH

  • Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The formation of cysts during IVF treatment may negatively influence the outcome. The aim of this study is to compare conservative management versus aspiration for functional ovarian cysts before ovarian stimulation for ART.

Materials and methods

Women who underwent IVF cycle with a long protocol, and developed ovarian cysts, they were randomly divided into a cyst aspiration group (n = 90) in which the cysts were aspirated after diagnosis and a no-intervention group (n = 90) for which the conservative treatment was continued following cyst diagnosis.

Results

The FSH level in women with ovarian cysts in the aspiration group was significantly higher than that in the no-intervention group (9.1 ± 4.5 vs. 6.5 ± 1.78 mIU/ml, p = 0.001). HMG requirement in that aspiration group was significantly higher than that in the non- intervention group (26.2 ± 9.7 vs. 21.85 ± 7.7, p = 0.0001). The embryo score in the no-intervention group was higher than the aspiration group (18 vs. 16, p = 0.0001).The cycle cancellation rate was significantly higher in the aspiration group than the no-intervention group. The pregnancy rate was higher but not significantly in the aspiration group than no-intervention group.

Conclusion

Cyst aspiration did not promote retrieved oocyte in quality and in number. Because cyst aspiration requires anesthesia and is expensive, conservative management is better and without improving the IVF outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Orvieto R, Zohav E, Scharf S, Rabinson J, Meltcer S, Anteby EY, Homburg R (2007) The influence of estradiol/follicle and estradiol/oocyte ratios on the outcome of controlled ovarian stimulation for in vitro fertilization. Gynecol Endocrinol 23(2):72–75

    Article  CAS  PubMed  Google Scholar 

  2. Ku SY, Choi YS, Jee BC, Suh CS, Choi YM, Kim JG, Moon SY, Kim SH (2005) A preliminary study on reduced dose (33 or 25 microg) gonadotropin-releasing hormone agonist long protocol for multifollicular ovarian stimulation in patients with high basal serum follicle-stimulating hormone levels undergoing in vitro fertilization-embryo transfer. Gynecol Endocrinol 21(4):227–231

    Article  CAS  PubMed  Google Scholar 

  3. Speroff L, Fritz MA (2005) Clinical gynecology endocrinology and infertility

  4. Liu HC, Lai YM, Davis O, Berkeley AS, Graf M, Grifo J, Cohen J, Rosenwaks Z (1992) Improved pregnancy outcome with gonadotropin releasing hormone agonist (GnRH-a) stimulation is due to the improvement in oocyte quantity rather than quality. J Assist Reprod Genet 9(4):338–344

    Article  CAS  PubMed  Google Scholar 

  5. Jenkins JM, Davies DW, Anthony F, Wood P, Gadd SG, Waston RH (1992) The detrimental influence of functional ovarian cyst during in vitro fertilization cycles. Human Reprod 7:776–780

    CAS  Google Scholar 

  6. Jenkins JM, Davies DW, Anthony F, Wood P, Rushen D, Masson GM, Thomas E (1993) The development of functional ovarian cyst during pituitary down regulation. Hum Reprod 8:1623–1627

    CAS  PubMed  Google Scholar 

  7. Feldburg D, Dicker D, Yeshaya A (1989) Ovarian cyst formation: a complication of gonadotropin-relasing hormone agonist therapy. Fertil Steril 51:42–44

    Google Scholar 

  8. Fiszbajn GE, Lipowicz RG, Elberger L, Grabia A, Dapier SD, Brugo-Olmedo SP (2000) Conservative management versus aspiration of functional ovarian cyst before ovarian stimulation for assisted reproduction. J Assisted Reprod Genet 17:206–263

    Google Scholar 

  9. Herman A, Ron-EI R, Golan A, Capsie E (1990) Follicle cysts after menstrual versus mid luteal administration of gonadotropin-releasing hormone in vitro fertilization. Fertil Steril 53:854–858

    CAS  PubMed  Google Scholar 

  10. Biljan MM, Lapensec L, Mahutte NG, Bissonnette F, Hemmings R (2000) Effect of functional ovarian cysts detected on the 7th day of GnRH agonist administration on the outcome of IVF treatment. Fertil Steril 74:941–945

    Article  CAS  PubMed  Google Scholar 

  11. Qublan HS, Amarin Z, Tahat YA, Smadi AZ, Kilani M (2006) Ovarian cyst formation following GnRH agonist administration in IVF cycles: incidence and impact. Hum Reprod 21(3):640–644

    Article  CAS  PubMed  Google Scholar 

  12. Keltz MD, Jones EE, Duleba AJ, Polcz T, Kennedy K, Olive DL (1995) Baseline cyst formation after luteal phase gonadotropin-releasing hormone agonist administration is linked to poor in vitro fertilization outcome. Fertil Steril 64:568–572

    CAS  PubMed  Google Scholar 

  13. Segal S, Shifren JL, Isaacson KB, Leykin L, Chang Y, Pal L, Toth TL (1999) Effect of a baseline ovarian cyst on the outcome of in vitro fertilization-embryo transfer. Fertil Steril 71(2):274–277

    Article  CAS  PubMed  Google Scholar 

  14. Owj M, Ashrafi M, Baghestani A (2004) Ovarian cyst formation and in vitro fertilization outcome. Int J Gynecol Obstet 87(3):258–259

    Article  CAS  Google Scholar 

  15. Rizk B, Tan SL, Kingsland C, Steer C, Mason BA, Campbell S (1990) Ovarian cyst aspiration and outcome of in vitro fertilization. Fertil Steril 54:661–664

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Leila Sekhavat.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Firouzabadi, R.D., Sekhavat, L. & Javedani, M. The effect of ovarian cyst aspiration on IVF treatment with GnRH. Arch Gynecol Obstet 281, 545–549 (2010). https://doi.org/10.1007/s00404-009-1195-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-009-1195-9

Keywords

Navigation