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Squamous cell carcinoma arising in a dermoid cyst of the ovary in pregnancy

  • Gynecologic oncology
  • Published:
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Abstract

Background

A rare complication of mature cystic teratoma of the ovary is malignant transformation, mostly being squamous cell carcinoma (SCC). Due to small case series, there are no established standard surgical and postoperative procedures.

Case

A 41-year-old pregnant woman presented with a right ovarian tumour. At 14 weeks of gestation, laparotomy with oophorectomy was performed. Histology revealed a pT1a poorly differentiated SCC with lymphovascular invasion. She delivered a healthy infant at 39 weeks of gestation. Nine weeks after delivery, she underwent complete surgical resection and was staged pT1a, pN0 (0/40) pMx, G0. No further treatment was given and 37 months later she is still free of disease.

Conclusion

For this rare entity complete surgical resection seems to be a safe treatment.

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References

  1. Peterson WF, Prevost EC, Edmunds FT, Hundley JM, Morris FK (1955) Benign cystic tumours of the ovary: a clinicostatistical study of 1007 cases with a review of the literature. Am J Obstet Gynecol 70:386–82

    Google Scholar 

  2. Whitecar MP, Turner S, Higby MK (1999) Adnexal masses in pregnancy: a review of 130 cases undergoing surgical management. Am J Obstet Gynecol 181:19–24

    Article  CAS  PubMed  Google Scholar 

  3. Usui R, Minakami H, Kosuge S, Iwasaki R, Ohwada M, Sato I (2000) A retrospective survey of clinical, pathologic and prognostic features of adnexal masses operated on during pregnancy. J Obstet Gynaecol Res 26:89–93

    Article  CAS  PubMed  Google Scholar 

  4. Stamp GWH, McConnell EM (1983) Malignancy rising in cystic ovarian teratomas. A report of 24 cases. Br J Obstet Gynaecol 90:671–675

    CAS  PubMed  Google Scholar 

  5. Oehler MK, Wain GV, Brand A (2003) Gynaecological malignancies in pregnancy: a review. Aust NZ J Obstet Gynaecol 43:414–420

    Article  Google Scholar 

  6. Kikkawa F, Ishikawa H, Tamakoshi K, Nawa A, Suganuma N, Tomoda Y (1997) Squamous cell carcinoma arising from mature cystic teratoma of the ovary: a clinicopathologic analysis. Obstet Gynecol 89:823–833

    Article  Google Scholar 

  7. Pins MR, Young RH, Daly WJ, Scully RE (1996) Primary squamous cell carcinoma of the ovary. A report of 37 cases. Am J Surg Pathol 20:823–833

    Article  CAS  PubMed  Google Scholar 

  8. Mori Y, Nishii H, Takabe K et al (2003) Preoperative diagnosis of malignant transformation arising from mature cystic teratoma of the ovary. Gyn Oncol 90:338–341

    Article  Google Scholar 

  9. Miyasaki K, Tokunga T, Katabuchi H, Ohba T, Tashiro H, Okamura H (1991) Clinical usefulness of serum squamous cell carcinoma antigen for early detection of squamous cell carcinoma arising in mature cystic teratoma of the ovary. Obstet Gynecol 78:562–565

    Google Scholar 

  10. Spitzer M, Kaushal N, Benjamin F (1998) Maternal CA 125 levels in pregnancy and the puerperium. J Reprod Med 43:387–393

    CAS  PubMed  Google Scholar 

  11. Kido A, Togashi K, Konishi I, Kataoka ML, Koyama T, Ueda H et al (1999) Dermoid cysts of the ovary with malignant transformation: MR appearance. Am J Roentgenol 172(2):445–449

    CAS  Google Scholar 

  12. Leiserowitz G (2006) Managing ovarian masses during pregnancy. Obstet Gynecol Surv 61(7):463–470

    Article  PubMed  Google Scholar 

  13. Mayer C, Miller DM, Ehlen TG (2002) Peritoneal implantation of squamous cell carcinoma following rupture of a dermoid cyst during laparoscopic removal. Gynecol Oncol 84:1–183

    Article  Google Scholar 

  14. Tseng C, Chou H, Huang K et al (1996) Squamous cell carcinoma arising in mature cystic teratoma of the ovary. Gynecol Oncol 63:364–370

    Article  CAS  PubMed  Google Scholar 

  15. Mekaru K, Kamiyama S, Masamoto H et al (2008) Squamous cell carcinoma arising in an ovarian mature cystic teratoma complicating pregnancy: a case report. Arch Gynecol Obstet 278:287–290

    Article  PubMed  Google Scholar 

  16. Rose PG, Tak WK, Reale FR (1993) Squamous cell carcinoma arising in a mature cystic teratoma with metastasis to the paraaortic nodes. Gynecol Oncol 50(1):131–133

    Article  CAS  PubMed  Google Scholar 

  17. Dos Santos L et al (2007) Squamous cell carcinoma arising in mature cystic teratoma of the ovary: a case series and review of the literature. Gynecol Oncol 105(2):321–324

    Article  PubMed  Google Scholar 

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There is no actual or potential conflict of interest.

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Correspondence to Helen Diana Budiman.

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Budiman, H.D., Burges, A., Rühl, I.M. et al. Squamous cell carcinoma arising in a dermoid cyst of the ovary in pregnancy. Arch Gynecol Obstet 281, 535–537 (2010). https://doi.org/10.1007/s00404-009-1193-y

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  • DOI: https://doi.org/10.1007/s00404-009-1193-y

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