Abstract
Background
Cystic tumors of ovary, whether benign, borderline, or malignant may be associated with mural nodule of various types, including sarcomas, sarcoma-like mural nodules (SLMN), and foci of anaplastic carcinoma. Cases of serous borderline ovarian tumor with mural nodules of mixed type are very rare.
Case
A 54-year-old woman referred with abdominal swelling. Imaging studies revealed a huge mass localized in pelvis and lower abdomen and grade 1–2 left renal hydronephrosis. Preoperative Ca-125 was 798 U/ml. In exploratory laparotomy there was a 16 cm mass adherent to lateral abdominal wall and intestines. Adhesiolysis and de-bulking surgery were performed including bilateral pelvic, para-aortic lymphadenectomy, appendectomy and omentectomy. Left ureter was found to be dilated because of the infiltration of distal part by the tumor, so distal ureteral resection and neoureterocystostomy were performed. Final pathology revealed borderline serous ovarian tumor with mural nodules which were consisted of SLMNs, multiple and sharply demarcated from the adjacent tumor, and sarcomatous nodules showing infiltrative appearance in metastatic regions. Mural nodules showed a positive reaction for vimentin and SMA but were negative for cytokeratin and also necrosis, hemorrhage, and 10–15 mitoses in 10 high power fields were noted. She had postoperative chemotherapy and follow-up is going on without metastases in her first year.
Conclusion
The existence of sarcomatous nodules combined with the SLMN necessitates a careful histologic analysis for treatment and the determination of prognosis. However, too few cases of mixed type mural nodules have been published to warrant a conclusion regarding their prognosis.
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References
Chang WC, Sheu BC, Lin MC, Chow SN, Huang SC (2005) Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report. Int J Gynecol Cancer 15(3):549–553
Tsuruchi N, Kaku T, Kinoshita H, Amada S, Saito T, Kamura T, Tsukamoto N, Nakano H (1993) Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma. Gynecol Oncol 50(2):259–263
Prat J, Scully RE (1979) Ovarian mucinous tumors with sarcoma-like mural nodules: a report of seven cases. Cancer 44(4):1332–1344
Prat J, Scully RE (1979) Sarcomas in ovarian mucinous tumors: a report of two cases. Cancer 44(4):1327–1331
Matias-Guiu X, Aranda I, Prat J (1991) Immunohistochemical study of sarcoma-like mural nodules in a mucinous cystadenocarcinoma of the ovary. Virchows Arch A Pathol Anat Histopathol 419(2):89–92
Fujii S, Konishi I, Kobayashi F, Okamura H, Yamabe H, Mori T (1985) Sarcoma-like mural nodules combined with a microfocus of anaplastic carcinoma in mucinous ovarian tumor. Gynecol Oncol 20(2):219–233
Bagué S, Rodríguez IM, Prat J (2002) Sarcoma-like mural nodules in mucinous cystic tumors of the ovary revisited: a clinicopathologic analysis of 10 additional cases. Am J Surg Pathol 26(11):1467–1476
Bruijn JA, Smit VT, Que DG, Fleuren GJ (1987) Immunohistology of a sarcomatous mural nodule in an ovarian mucinous cystadenocarcinoma. Int J Gynecol Pathol 6(3):287–293
McCullough J, Batman P, Parker D (1988) Sarcoma-like nodules in cystic ovarian tumours. J Clin Pathol 41(9):1028–1029
Tsujimura T, Kawano K (1992) Rhabdomyosarcoma coexistent with ovarian mucinous cystadenocarcinoma: a case report. Int J Gynecol Pathol 11(1):58–62
Baergen RN, Rutgers JL (1994) Mural nodules in common epithelial tumors of the ovary. Int J Gynecol Pathol 13(1):62–72
Russell P, Wills EJ, Schweitzer P, Bannatyne PM (1981) Mucinous ovarian tumors with giant cell mural nodules. A report of two cases. Diagn Gynecol Obstet 3(3):233–249
Prat J, Young RH, Scully RE (1982) Ovarian mucinous tumors with foci of anaplastic carcinoma. Cancer 50(2):300–304
Czernobilsky B, Dgani R, Roth LM (1983) Ovarian mucinous cystadenocarcinoma with mural nodule of carcinomatous derivation. A light and electron microscopic study. Cancer 51(1):141–148
Yamana K, Kinoshita T, Nakano R, Morimatsu M, Nakashima T (1984) Anaplastic giant cell tumor with mucinous cystadenocarcinoma of the ovary. Origin of the giant cells. Acta Pathol Jpn 34(2):399–402
Hayman JA, Ostör AG (1985) Ovarian mucinous tumour with a focus of anaplastic carcinoma: a case report. Pathology 17(4):591–593
Chan YF, Ho HC, Yau SM, Ma L (1989) Ovarian mucinous tumor with mural nodules of anaplastic carcinoma. Gynecol Oncol 35(1):112–119
Søndergaard G, Kaspersen P (1991) Ovarian and extraovarian mucinous tumors with solid mural nodules. Int J Gynecol Pathol 10(2):145–155
Nichols GE, Mills SE, Ulbright TM, Czernobilsky B, Roth LM (1991) Spindle cell mural nodules in cystic ovarian mucinous tumors. A clinicopathologic and immunohistochemical study of five cases. Am J Surg Pathol 15(11):1055–1062
Chen RD, Ho WL (1993) Ovarian mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma: report of a case and review of the literature. Gaoxiong Yi Xue Ke Xue Za Zhi 9(3):178–182
Buzzi A, Pezzica E, Crescini C (1996) A mucinous ovarian tumor with foci of anaplastic carcinoma. Minerva Ginecol 48(4):163–166
Hong SR, Chun YK, Kim YJ, Lim KT, Kim HS (1998) Ovarian mucinous cystadenoma with mural nodule of anaplastic carcinoma. J Korean Med Sci 13(6):680–684
Rodríguez IM, Prat J (2002) Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas. Am J Surg Pathol 26(2):139–152
Guilbeau C, Soubeyrand MS, Devillebichot C, Sage M, Collin F, Arnould L (2003) Mural nodules of anaplastic carcinoma in bilateral ovarian borderline mucinous cystadenoma: a case report. Ann Pathol 23(4):340–344
Tamiolakis D, Venizelos I, Nikolaidou S, Lambropoulou M, Bolioti S, Papadopoulos N (2005) Ovarian mucinous cystadenocarcinoma with mural nodule of anaplastic carcinoma and synchronous cervical squamous carcinoma. Cesk Patol 41(2):66–70
De Rosa G, Donofrio V, De Rosa N, Fulciniti F, Zeppa P (1991) Ovarian serous tumor with mural nodules of carcinomatous derivation (sarcomatoid carcinoma): report of a case. Int J Gynecol Pathol 10(3):311–318
Chakrabarti S, Konar A, Biswas S, Das S (2005) Sarcoma-like mural nodules in ovarian mucinous cystadenomas—a report of two cases. Indian J Med Sci 59(11):499–502
Huang TY, Chen JT, Ho WL (2005) Ovarian serous cystadenoma with mural nodules of genital rhabdomyoma. Hum Pathol 36(4):433–435
Agarwal K, Meenakshi Agarwal C, Jain K (2004) Sarcoma-like mural nodule in an ovarian mucinous cystadenoma: a case report. Indian J Pathol Microbiol 47(2):226–228
Nakamura E, Shimizu M, Mikami Y, Kawai J, Manabe T (1998) Ovarian mucinous cystadenocarcinoma with malignant mural nodules. Pathol Int 48(8):645–648
Hameed A, Ying AJ, Keyhani-Rofagha S, Xie D, Copeland LJ (1997) Ovarian mucinous cystadenoma associated with mural leiomyomatous nodule and massive ovarian edema. Gynecol Oncol 67(2):226–229
Mizuno K, Hirata S, Kasai T, Yasumizu T, Kato J (1996) Mucinous cystadenocarcinoma with sarcoma-like mural nodules arising in a mature cystic teratoma of the ovary: a case report. J Obstet Gynaecol Res 22(5):461–465
Jones K, Diaz JA, Donner LR (1996) Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma. Int J Gynecol Pathol 15(2):167–170
Kataoka A, Nishida T, Ueyama T, Okina H, Yakushiji M (1996) Ovarian mucinous cystadenocarcinoma with sarcoma-like mural nodules. J Obstet Gynaecol Res 22(1):51–56
Hamada T, Sasaguri T, Tanimoto A, Arima N, Nakano R, Miyayama H, Sasaguri Y (1995) Ovarian mucinous cystadenocarcinoma with sarcoma-like mural nodules. J Surg Oncol 58(3):201–207
Verma RN, Bhangui GR, Rao MK (1993) Sarcoma-like nodule in ovarian mucinous tumour (a case report). Indian J Cancer 30(1):38–41
Suurmeijer AJ (1991) Carcinosarcoma-like mural nodule in an ovarian mucinous tumour. Histopathology 18(3):268–271
Lifschitz-Mercer B, Dgani R, Jacob N, Fogel M, Czernobilsky B (1990) Ovarian mucinous cystadenoma with leiomyomatous mural nodule. Int J Gynecol Pathol 9(1):80–85
Clarke TJ (1987) Sarcoma-like mural nodules in cystic serous ovarian tumours. J Clin Pathol 40(12):1443–1448
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Gungor, T., Altınkaya, S.O., Akbay, S. et al. Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review. Arch Gynecol Obstet 281, 485–490 (2010). https://doi.org/10.1007/s00404-009-1180-3
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DOI: https://doi.org/10.1007/s00404-009-1180-3