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Vitreous vascular endothelial growth factor level during gestation

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Abstract

Purpose

To evaluate the vitreous VEGF level alterations and its correlation with its plasma level if any, in gestation.

Methods

The blood and vitreous sampling procedures were performed before, during (20–23 days of gestation), and after gestation (2 months after birth) from seven White New Zealand rabbits. Blood samples were centrifuged then supernatants and vitreous samples were stored at −80°C until assay. Measurements of serum and vitreous VEGF165 were done by ELISA.

Results

The median plasma and vitreous VEGF165 concentrations were 36.61 pg/ml (range 19.17–40.30), 14.92 pg/ml (range 8.95–15.20); 58.30 pg/ml (range 32.60–11.53), 20.51 pg/ml (range 11.94–21.26); and 35.30 pg/ml (range 27.30–39.60), 13.05 pg/ml (range 9.33–16.04) before, during and after gestation, respectively. Both the plasma and the vitreous VEGF165 concentration during gestational period were significantly higher than pre-gestational period (P = 0.028, P = 0.018) and post-gestational period (P = 0.043, P = 0.028). The intravitreal VEGF165 concentrations appeared to correlate with plasma VEGF165 levels (r = 0.940, P = 0.002) only in the gestational period.

Conclusion

Vitreous VEGF levels increase in positive correlation with plasma VEGF during pregnancy. Further prospective studies are needed to support this finding.

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, İnönü University School of Medicine, 44100, Malatya, Turkey

    Ilgın Türkçüoğlu

  2. Department of Ophthalmology, İnönü University School of Medicine, Malatya, Turkey

    Peykan Türkçüoğlu & Ahmet Taşar

  3. Department of Biochemistry, İnönü University School of Medicine, Malatya, Turkey

    Aysun Bay Karabulut

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  1. Ilgın Türkçüoğlu
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Correspondence to Ilgın Türkçüoğlu.

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Türkçüoğlu, I., Türkçüoğlu, P., Karabulut, A.B. et al. Vitreous vascular endothelial growth factor level during gestation. Arch Gynecol Obstet 281, 417–421 (2010). https://doi.org/10.1007/s00404-009-1144-7

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  • DOI: https://doi.org/10.1007/s00404-009-1144-7

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