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Comparing GnRH agonist long protocol and gnrh antagonist protocol in outcome the first cycle of ART



This prospective study evaluated the efficacy of gonadotropin-releasing hormone (GnRH) antagonist protocol in comparison with the GnRH agonist protocol in the first cycle of assisted reproductive technique (ART).


We randomized 235 patients undergoing ART for the first time. The first group was stimulated with a standard long protocol and the second group stimulated with GnRH antagonis.


There was no statistically significant difference in the age, infertility cause, basal FSH, BMI, the number of oocytes retrieved, number of M2 oocytes, embryo obtained and endometrial thickness between the two groups. But Serum estradiol, consumption of gonadotropins and ovarian hyperstimulation syndrome were significantly lower in the antagonist protocol. Cancellation rate of embryo transfer due to poor-quality embryo in the antagonist protocol was higher, but it was not significant. There was no significant difference in the clinical pregnancy and ongoing pregnancy between the two groups.


GnRH-antagonist is an effective, safe, and well-tolerated alternative to agonist in the first cycle of ART.

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The authors are grateful to the patients who participate in this study, the infertility nurses and embryology staff of the Research and Clinical Center for Infertility.

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Correspondence to Shahnaz Ahmadi.

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Firouzabadi, R.D., Ahmadi, S., Oskouian, H. et al. Comparing GnRH agonist long protocol and gnrh antagonist protocol in outcome the first cycle of ART. Arch Gynecol Obstet 281, 81–85 (2010).

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  • GnRH antagonist
  • GnRH agonist
  • Pregnancy rate
  • Assisted reproductive technology
  • Ovarian stimulation