Abstract
Introduction
Splenic metastasis from endometrial carcinoma is a rare clinical event, with only 11 cases documented previously in the literature.
Case report
A 58-year-old woman had surgery and radiotherapy for stage IIB endometrial carcinoma. Eighteen months later, PET scan discovered a hypermetabolic splenic mass and two hypermetabolic lung nodules. Spleen biopsy showed metastasis from endometrial carcinoma. Chemotherapy with six cycles of cyclophosphamide, adriamycin and cisplatin effected a partial response of the splenic and lung metastasis. After few months, however, splenectomy was performed because of substantial growth of the spelnic metastasis and it confirmed that the splenic metastasis was of endometrial origin and solitary in the peritoneal cavity. After splenectomy, the patient received chemotherapy with six cycles of paclitaxel. To date, 6 months after splenectomy, she is alive with no intraperitoneal disease and with few stable lung metastases.
Conclusion
This is the 12th reported case of splenic metastasis from endometrial carcinoma. Splenic metastasis from endometrial carcinoma is usually solitary splenic metastasis limited to the splenic parenchyma. Splenectomy is an appropriate treatment to avoid splenic rupture, splenic vein thrombosis and painful splenomegaly, to circumvent the splenic metastasis being a source of secondary metastatic disease, and to provide the potential for cure or extended survival. Since patients with splenic metastasis may be asymptomatic and the interval between the diagnoses of endometrial carcinoma and splenic metastasis may be prolonged, careful and extended follow-up after primary treatment of endometrial carcinoma is warranted.
References
Berge T (1974) Splenic metastases frequencies and patterns. Acta Pathol Microbiol Scand 82:499–506
Lam KY, Tang V (2000) Metastatic tumors to the spleen: a 25-year clinicopathologic study. Arch Pathol Lab Med 124:526–530
Lee SS, Morgenstern L, Phillips EH, Hiatt JR, Margulies DR (2000) Splenectomy for splenic metastases: a changing clinical spectrum. Am Surg 66:837–840
Sauer J, Sobolewski K, Dommisch K (2008) Splenic metastases—not a frequent problem, but an underestimate location of metastases: epidemiology and course. J Cancer Res Clin Oncol (Epub ahead of print). doi:10.1007/s00432-008-0502-3
Kyzer S, Koren R, Klein B, Chaimoff C (1998) Giant splenomegaly caused by splenic metastases of melanoma. Eur J Surg Oncol 24:336–337. doi:10.1016/S0748-7983(98)80021-8
Furukawa N (2007) Solitary splenic metastasis of ovarian cancer. Arch Gynecol Obstet 275:499–502. doi:10.1007/s00404-006-0274-4
Kinoshita A, Nakano M, Fukuda M, Kasai T, Suyama N, Inoue K, Nakata T, Shigematsu K, Oka M, Hara K (1995) Splenic metastasis from lung cancer. Neth J Med 47:219–223. doi:10.1016/0300-2977(95)00011-8
Morris M, Gershenson DM, Burke TW, Wharton JT, Copeland LJ, Rutledge FN (1991) Splenectomy in gynecologic oncology: indications, complications, and technique. Gynecol Oncol 43:118–122. doi:10.1016/0090-8258(91)90056-B
Farias-Eisner R, Braly P, Berek JS (1993) Solitary recurrent metastasis of epithelial ovarian cancer in the spleen. Gynecol Oncol 48:338–341. doi:10.1006/gyno.1993.1059
Bristow RE, Santillan A, Zahurak ML, Gardner GJ, Giuntoli RL, Armstrong DK (2006) Salvage cytoreductive surgery for recurrent endometrial cancer. Gynecol Oncol 103:281–287. doi:10.1016/j.ygyno.2006.03.011
Awtrey CS, Cadungog MG, Leitao MM, Alektiar KM, Aghajanian C, Hummer AJ, Barakat RR, Chi DS (2006) Surgical resection of recurrent endometrial carcinoma. Gynecol Oncol 102:480–488. doi:10.1016/j.ygyno.2006.01.007
Sohaib SA, Houghton SL, Meroni R, Rockall AG, Blake P, Reznek RH (2007) Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis. Clin Radiol 62:28–34. doi:10.1016/j.crad.2006.06.015
Kopacz A, Szolkowski B, Kucharski A (1970) Delayed single metastasis of uterine cancer to the spleen. Pol Przegl Chir 42:1467–1470 (in Polish)
Klein B, Stein M, Kuten A, Steiner M, Barshalom D, Robinson E, Gal D (1987) Splenomegaly and solitary spleen metastasis in solid tumors. Cancer 60:100–102. doi:10.1002/1097-0142(19870701)60:1<100::AID-CNCR2820600118>3.0.CO;2-9
Jorgensen LN, Chrintz H (1988) Solitary metastatic endometrial carcinoma of the spleen. Acta Obstet Gynecol Scand 67:91–92. doi:10.3109/00016348809004176
Gilks CB, Acker BD, Clement PB (1989) Recurrent endometrial adenocarcinoma: presentation as a splenic mass mimicking malignant lymphoma. Gynecol Oncol 33:209–211. doi:10.1016/0090-8258(89)90554-4
Arend P, Amuli M, Algaba R, Blondiau JV, Wauters G, Chamiec M, Malarme M, Ardichvilli D, Van Gysel JP (1992) Solitary splenic metastasis of endometrial adenocarcinoma. A case report and review of the literature. J Gynecol Obstet Biol Reprod (Paris) 21:182–184 (in French)
Hamy A, Letessier E, Guillard Y, Paineau J, Visset J (1995) Splenectomy for isolated splenic metastasis from endometrial carcinoma. Acta Obstet Gynecol Scand 74:745–746. doi:10.3109/00016349509021186
Giuliani A, Caporale A, Di Bari M, Demoro M, Mingazzini P (1999) Isolated splenic metastasis from endometrial carcinoma. J Exp Clin Cancer Res 18:93–96
Agha-Mohammadi S, Calne RY (2001) Solitary splenic metastasis: case report and review of the literature. Am J Clin Oncol 24:306–310. doi:10.1097/00000421-200106000-00020
Gogas H, Ignatiadis T, Markopoulos C, Karageorgopoulou S, Floros D, Vaiopoulos G (2004) Solitary spleen metastasis and amyloidosis in a patient with endometrial cancer. Eur J Gynaecol Oncol 25:391–393
Hadjileontis C, Amplianitis I, Valsamides C, Harisis G, Nepka H, Kafanas A (2004) Solitary splenic metastasis of endometrial carcinoma ten years after hysterectomy. Case report and review of the literature. Eur J Gynaecol Oncol 25:233–235
Takahashi H, Yano H, Monden T, Kinoshita T (2004) Hand-assisted laparoscopic splenectomy for solitary splenic metastasis from uterine corpus carcinoma. Surg Endosc 18:346. Available at http://www.springerlink.com; doi:10.1007/s00464-003-4509-1
Conflict of interest statement
We declare that we have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Piura, B., Rabinovich, A., Apel-Sarid, L. et al. Splenic metastasis from endometrial carcinoma: report of a case and review of literature. Arch Gynecol Obstet 280, 1001–1006 (2009). https://doi.org/10.1007/s00404-009-1039-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-009-1039-7