Abstract
Purpose
To elucidate the clinicopathologic features of lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, we examined three Japanese cases.
Methods
We collected three cases of LELC of the uterine cervix between 2000 and 2007. We examined these patients’ clinicopathologic data, Epstein–Barr virus (EBV) and human papilloma virus (HPV) infectious status, and infiltrated lymphocyte population.
Results
Our patients had disease Fédération Internatinale de Gynécologie et d’Obstétrique stages I and II. All of them were free of disease at the time of the study. Macroscopically, one of the three tumors was polypoid. All tumor cells were negative for EBV and HPV using in situ hybridization and immunohistochemistry. The inflammatory background contained many CD3+ and CD8+ cells, but there were few CD4+, CD20+, or CD79a+ cells.
Conclusions
In our Japanese series, LELC of the uterine cervix showed good prognosis, and there is no relationship between this carcinoma and EBV or HPV infection.
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Takai, N., Nakamura, S., Goto, K. et al. Lymphoepithelioma-like carcinoma of the uterine cervix. Arch Gynecol Obstet 280, 725–727 (2009). https://doi.org/10.1007/s00404-009-0993-4
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DOI: https://doi.org/10.1007/s00404-009-0993-4