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Cisplatinum and docetaxel for ovarian cancer in pregnancy

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There is limited data on chemotherapy for advanced ovarian cancer during pregnancy. Most women received cisplatin-based chemotherapy. There are no published reports on the use of docetaxel for ovarian cancer in pregnancy.


A 32-year-old pregnant lady underwent laparatomy at 18-week gestation for ruptured ovarian cyst. The pregnancy was the result of in vitro fertilization with intracytoplasmic sperm injection. Left salpingo-oophorectomy and omental biopsy were done. A diagnosis of stage IIIC, poorly differentiated papillary serous adenocarcinoma of the ovary was made. She was given four cycles of cisplatinum and docetaxel followed by cesarean hysterectomy, right salpingo-oophorectomy, and cytoreductive surgery. The mother is well and has completed six cycle of chemotherapy.


This is the first report on the use of docetaxel during pregnancy for ovarian cancer.

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  1. Mahdavi A, Pejovic T, Nezhat F (2006) Induction of ovulation and ovarian cancer: a critical review of the literature. Fertil Steril 85:819–826. doi:10.1016/j.fertnstert.2005.08.061

    Article  PubMed  CAS  Google Scholar 

  2. Venn A, Watson L, Bruinsma F, Giles G, Healy D (1999) Risk of cancer after use of fertility drugs with in-vitro fertilization. Lancet 354:1586–1590. doi:10.1016/S0140-6736(99)05203-4

    Article  PubMed  CAS  Google Scholar 

  3. Attar E, Berkman S, Topuz S, Baysal B, Akhan S, Chamber JT (2004) Evolutive peritoneal disease after conservative management and the use of infertility drugs in a patient with stage IIIC borderline micro-papillary serous carcinoma (MPSC) of the ovary: case report. Hum Reprod 19:1472–1475. doi:10.1093/humrep/deh226

    Article  PubMed  Google Scholar 

  4. Zhao XY, Huang HF, Lian LJ, Lang JH (2006) Ovarian cancer in pregnancy: a clinicopathologic analysis of 22 cases and review of the literature. Int J Gynecol Cancer 16(1):8–15. doi:10.1111/j.1525-1438.2006.00422.x

    Article  PubMed  CAS  Google Scholar 

  5. Pentheroudakis G, Pavlidis N (2006) Cancer and pregnancy: poena magna, not anymore. Eur J Cancer 42:126–140

    Article  PubMed  Google Scholar 

  6. Amant F, Van Calsteren K, Vergote I, Ottevanger N (2008) Gynecologic oncology in pregnancy. Crit Rev Oncol Hematol 67:187–195. doi:10.1016/j.critrevonc.2008.01.006

    Article  PubMed  Google Scholar 

  7. Machado F et al (2007) Ovarian cancer during pregnancy: analysis of 15 cases. Gynecol Oncol 105:446–450. doi:10.1016/j.ygyno.2007.01.002

    Article  PubMed  Google Scholar 

  8. Vasey PA, Jayson GC, Gordon A et al (2004) Phase III randomized trial of docetaxel–carboplatin versus paclitaxel–carboplatin as first-line chemotherapy for ovarian carcinoma. J Natl Cancer Inst 96:1682–1691

    Article  PubMed  CAS  Google Scholar 

  9. Tabata T, Nishiura K, Tanida K, Kondo E, Okugawa T, Sagawa N (2008) Carboplatin chemotherapy in a pregnant patient with undifferentiated ovarian carcinoma: case report and review of the literature. Int J Gynecol Cancer 18:181–184

    Article  PubMed  CAS  Google Scholar 

  10. Mir O, Berveiller P, Ropert S, Goffinet F, Goldwasser F (2008) Use of platinum derivatives during pregnancy. Cancer 113:3069–3074. doi:10.1002/cncr.23935

    Article  PubMed  CAS  Google Scholar 

  11. Kim JH, Kim HS, Sung CW, Kim KJ, Kim CH, Lee KY (2008) Docetaxel, gemcitabine, and cisplatin administered for non-small cell lung cancer during the first and second trimester of an unrecognized pregnancy. Lung Cancer 59:270–273. doi:10.1016/j.lungcan.2007.06.017

    Article  PubMed  Google Scholar 

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Correspondence to Abdulrahim A. Rouzi.

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Rouzi, A.A., Sahly, N.N., Sahly, N.F. et al. Cisplatinum and docetaxel for ovarian cancer in pregnancy. Arch Gynecol Obstet 280, 823–825 (2009).

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