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A case of nephrogenic diabetes insipidus caused by partial bilateral ureteral obstruction due to advanced stage ovarian carcinoma

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Abstract

Nephrogenic diabetes insipidus (NDI) secondary to chronic urinary tract obstruction is a rare condition. The exact cause is unknown; it is likely that increased collecting duct pressures cause damage to the tubular epithelium, resulting in insensitivity to the antidiuretic hormone (ADH). We report a case of NDI associated with ureteral obstruction caused by advanced stage ovarian carcioma in a 20-year-old girl. After debulcking surgery, massive polyuria continued. Several administrations of an ADH analog were ineffective in reducing urine output, suggesting a possible relationship of massive polyuria with NDI. Following oral administration of a thiazide diuretic, known to exert antidiuretic action in NDI, the urine output was dramatically reduced. This case suggests that ureteral obstruction due to ovarian mass may cause NDI and after the surgery thiazide diuretics are effective in reducing urine output in NDI with ureteral obstruction.

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Authors and Affiliations

  1. Dr. Zekai Tahir Burak Woman’s Health Education and Research Hospital, Ankara, Turkey

    Tayfun Gungor, Mahmut Kuntay Kokanalý, Demet Öztürkkan, Omer L. Tapısız & Leyla Mollamahmutoglu

  2. Cukurambar Mahallesi, 441. sokak, No: 16/6, Cankaya, Ankara, Turkey

    Mahmut Kuntay Kokanalý

Authors
  1. Tayfun Gungor
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  2. Mahmut Kuntay Kokanalý
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  3. Demet Öztürkkan
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  4. Omer L. Tapısız
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  5. Leyla Mollamahmutoglu
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Correspondence to Mahmut Kuntay Kokanalý.

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Gungor, T., Kokanalý, M.K., Öztürkkan, D. et al. A case of nephrogenic diabetes insipidus caused by partial bilateral ureteral obstruction due to advanced stage ovarian carcinoma. Arch Gynecol Obstet 280, 679–681 (2009). https://doi.org/10.1007/s00404-009-0987-2

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  • DOI: https://doi.org/10.1007/s00404-009-0987-2

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