Abstract
As a important part of endocrine surgery, laparoscopic surgery has become the gold standard for the treatment of benign symptomatic ovarian cysts refractory to medical treatment. In fact, the stripping technique seems to be the most common technique used for ovarian cyst surgery. After stripping the cystic wall, the subsequent bleeding of the ovarian stromal wound ground is usually controlled by bipolar coagulation or/and by suturing. Potentially, the surgery-induced ovarian tissue damage will be increased by heat and/or by sutures. In respect to intraovarian hemostasis, the use of gelantine–thrombin-matrix might protect from additional ovarian tissue damage, which is of great importance for the ovarian reproductive function in woman. For the first time, our data do support a promising laparoscopic technique demonstrating ovarian cystectomy without any bipolar coagulation and/or suturing of ovarian tissue using a gelantine–thrombin-matrix sealant (FloSeal©) as a new tool to control post-cystectomy ovarian wound bleeding.
References
Canis M, Pouly JL, Tamburro S, Mage G, Wattiez A, Bruhat MA (2001) Ovarian response during IVF-embryo transfer cycles after laparoscopic ovarian cystectomy for endometriotic cysts of >3 cm in diameter. Hum Reprod 16:2583–2586. doi:10.1093/humrep/16.12.2583
Somigliana E, Ragni G, Infantino M, Benedetti F, Arnoldi M, Crosignani PG (2006) Does laparoscopic removal of nonendometriotic benign ovarian cysts affect ovarian reserve? Acta Obstet Gynecol 85:74–77
Muzii L, Bellati F, Palaia I, Plotti F, Manci N, Zullo MA, Angioli R, Panici PB (2005) Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part I: clinical results. Hum Reprod 20:1981–1986. doi:10.1093/humrep/dei007
Muzii L, Bellati F, Bianchi A, Palaia I, Manci N, Zullo MA, Angioli R, Panici PB (2005) Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part II: pathological results. Hum Reprod 20:1987–1992. doi:10.1093/humrep/deh851
FloSeal Hemostatic Matrix Instructions for Use. www.baxter.com/products/biopharmaceuticals/downloads/FloSeal_PI.pdf
US food and drug administration. Summary of safety and effectiveness: FloSeal1 matrix hemostatic sealant. PMA P990009, 8 Dec 1999
Oz MC, Cosgrove DM 3rd, Badduke BR, Hill JD, Flannery MR, Palumbo R, Topic N (2000) Controlled clinical trial of a novel hemostatic agent in cardiac surgery. Ann Thorac Surg 69:1376–1382. doi:10.1016/S0003-4975(00)01194-2
Chandra RK, Conley DB, Haines GK 3rd, Kern RC (2005) Long-term effects of FloSeal packing after endoscopic sinus surgery. Am J Rhinol 19:240–243
Pursifull NF, Morey AF (2007) Tissue glues and nonsuturing techniques. Curr Opin Urol 17:396–401. doi:10.1097/MOU.0b013e3282f0d683
Ho H, Schwentner C, Neururer R, Steiner H, Bartsch G, Peschel R (2008) Robotic-assisted laparoscopic partial nephrectomy: surgical technique and clinical outcomes at 1 year. BJU Int 2008(Oct):6. Epub ahead of print
Breda A, Stepanian SV, Lam JS, Liao JC, Gill IS, Colombo JR, Guazzoni G, Stifelman MD, Perry KT, Celia A, Breda G, Fornara P, Jackman SV, Rosales A, Palou J, Grasso M, Pansadoro V, Disanto V, Porpiglia F, Milani C, Abbou CC, Gaston R, Janetschek G, Soomro NA, De la Rosette JJ, Laguna PM, Schulam PG (2007) Use of haemostatic agents and glues during laparoscopic partial nephrectomy: a multi-institutional survey from the United States and Europe of 1347 cases. Eur Urol 52:798–803. doi:10.1016/j.eururo.2007.02.035
Henkel A, Cooper RA, Ward KA, Bova D, Yao K (2008) Malignant-appearing microcalcifications at the lumpectomy site with the use of FloSeal hemostatic sealant. AJR Am J Roentgenol 191:1371–1373. doi:10.2214/AJR.08.1041
Han LY, Schimp V, Oh JC, Ramirez PT (2004) A gelatin matrix-thrombin tissue sealant (FloSeal) application in the management of groin breakdown after inguinal lymphadenectomy for vulvar cancer. Int J Gynecol Cancer 14:621–624. doi:10.1111/j.1048-891X.2004.14411.x
Cillo JE Jr, Sinn D, Truelson JM (2005) Management of middle meningeal and superficial temporal artery hemorrhage from total temporomandibular joint replacement surgery with a gelatin-based hemostatic agent. J Craniofac Surg 16:309–312. doi:10.1097/00001665-200503000-00020
Gazzeri R, Galarza M, Neroni M, Alfieri A, Esposito S (2008) Minimal craniotomy and matrix hemostatic sealant for the treatment of spontaneous supratentorial intracerebral hemorrhage. J Neurosurg [Epub ahead of print]
Cappabianca P, Esposito F, Esposito I, Cavallo LM, Leone CA (2009) Use of a thrombin-gelatin haemostatic matrix in endoscopic endonasal extended approaches: technical note. Acta Neurochir (Wien) 151:69–77. doi:10.1007/s00701-008-0172-6
Fiss I, Danne M, Stendel R (2007) Use of gelantin-thrombin matrix hemostatic sealant in cranial neurosurgery. Neurol Med Surg 47:462–467
Muzii L, Perniola G, Plotti F (2007) A new technique for laparoscopic stripping of endometrioma: FloSeal hemostatic agent for hemostasis of the ovarian wall. J Minim Invasive Gynecol 14:S130. doi:10.1016/j.jmig.2007.08.338 Abstract
Angioli R, Muzii L, Montera R, Damiani P, Bellati F, Plotti F, Zullo MA, Oronzi I, Terranova C, Panici PB. (2009) Feasibility of the use of novel matrix hemostatic sealant (FloSeal) to achieve hemostasis during laparoscopic excision of endometrioma. J Minim Invasive Gynecol. doi:10.1016/j.jmig.2008.11.007
Eltabbakh GH, Charboneau AM, Eltabbakh NG (2008) Laparoscopic surgery for large benign ovarian cysts. Gynecol Oncol 108:72–76. doi:10.1016/j.ygyno.2007.08.085
Mahdavi A, Berker B, Nezhat C, Nezhat F, Nezhat C (2004) Laparoscopic management of ovarian cysts. Obstet Gynecol Clin North Am 31:581–592. doi:10.1016/j.ogc.2004.05.011
Candiani M, Barbieri M, Bottani B, Bertulessi C, Vignali M, Agnoli B, Somigliana E, Busacca M (2005) Ovarian recovery after laparoscopic enucleation of ovarian cysts: insights from echographic short-term postsurgical follow-up. J Minim Invasive Gynecol 12:409–414. doi:10.1016/j.jmig.2005.06.006
Bussaca M, Riparini J, Somniagliana E, Oggioni G, Izzo S, Vignali M, Candiani M (2006) Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol 195:421–425. doi:10.1016/j.ajog.2006.03.064
Hachisuga T, Kawarabayashi T (2002) Histopathological analysis of laparoscopically treated ovarian endometriotic cysts with special reference to loss of follicles. Hum Reprod 17:432–435. doi:10.1093/humrep/17.2.432
Nargund G, Cheng WC, Parson J (1995) The impact of ovarian cystectomy on ovarian response to stimulation during in vitro fertilization cycles. Hum Reprod 11:81–83
Thomas PJ, Tawfic SN (2008) Eosinophil-rich inflammatory response to FloSeal hemostatic matrix presenting as postoperative pelvic pain. Am J Obstet Gynecol [Epub ahead of print]
Conflict of interest statement
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ebert, A.D., Hollauer, A., Fuhr, N. et al. Laparoscopic ovarian cystectomy without bipolar coagulation or sutures using a gelantine–thrombin matrix sealant (FloSeal©): first support of a promising technique. Arch Gynecol Obstet 280, 161–165 (2009). https://doi.org/10.1007/s00404-009-0985-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-009-0985-4