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Synchronous diagnosis of multiple tumours in a postmenopausal woman

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Abstract

We report an unusual case of a postmenopausal woman that was diagnosed with multiple tumours derived from different embryogenic tissues. She presented with postmenopausal vaginal bleeding. Clinical examination revealed a large pelvic mass, tender on palpation. Serum CA-125 level was elevated at 8,985 kU/l (normal range 0–35). A CT scan showed a malignant-appearing right ovarian mass with a peritoneal nodule, small amount of free fluid in the pelvis and evidence of a colonic intussusception. The patient underwent total abdominal hysterectomy, bilateral salpingo-ophorectomy, partial omentectomy and right hemicolectomy with side-to-side anastomosis. Histopathology showed a Grade 3 endometrial adenocarcinoma. Both ovaries were completely replaced by partially necrotic poorly differentiated endometrioid adenocarcinoma. Small deposits of metastatic adenocarcinoma were seen within the omentum. Sections from the retroperitoneal mass showed a low-grade liposarcoma. A large polypoid tumour within the right colon was a tubulo-villous adenoma.

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References

  1. Işin Doğan Ekici A, Küçükali T, Coşkun Salman M et al (2006) Triple simultaneous primary gynecological malignancies in a 56-year-old patient. Int J Gynecol Cancer 16:1947–1950. doi:10.1111/j.1525-1438.2006.00704.x

    Article  PubMed  Google Scholar 

  2. Phupong V, Khemapech N, Triratanachat S (2007) Triple synchronous primary cervical, endometrial and ovarian cancer with four different histologic patterns. Arch Gynecol Obstet 276:655–658. doi:10.1007/s00404-007-0392-7

    Article  PubMed  Google Scholar 

  3. Zaino R, Whitney C, Brady MF et al (2001) Simultaneously detected endometrial and ovarian carcinomas-a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol 83:355–362. doi:10.1006/gyno.2001.6400

    Article  PubMed  CAS  Google Scholar 

  4. Soliman PT, Slomovitz BM, Broaddus RR et al (2004) Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol 94:456–462. doi:10.1016/j.ygyno.2004.05.006

    Article  PubMed  Google Scholar 

  5. Scully R, Young R, Clement P et al (1998) Atlas of tumors pathology. tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. Armed Forces Institute of Pathology, Washington, DC, pp 107–127

    Google Scholar 

  6. Nishimura N, Hachisuga T, Nabeshima K et al (2005) Synchronous endometrial and ovarian carcinomas: analysis of genetic relationship of the tumors. Int J Oncol 27:1519–1526

    PubMed  CAS  Google Scholar 

  7. Ricci R, Komminoth P, Bannwart F et al (2003) PTEN as a molecular marker to distinguish metastatic from primary synchronous endometrioid carcinomas of the ovary and the uterus. Diagn Mol Pathol 12:71–78. doi:10.1097/00019606-200306000-00002

    Article  PubMed  CAS  Google Scholar 

  8. Moreno-Bueno G, Gamallo C, Pérez-Gallego L et al (2001) beta-Catenin expression pattern, beta-catenin gene mutations and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas. Diagn Mol Pathol 10:116–122. doi:10.1097/00019606-200106000-00008

    Article  PubMed  CAS  Google Scholar 

  9. Lawrence W Jr, Donegan WL, Natarajan N et al (1987) Adult soft tissue sarcomas. A pattern of care survey of the American College of Surgeons. Ann Surg 205:349–359. doi:10.1097/00000658-198704000-00003

    Article  PubMed  Google Scholar 

  10. Porter GA, Baxter NN, Pisters PW (2006) Retroperitoneal sarcoma: a population-based analysis of epidemiology, surgery, and radiotherapy. Cancer 106:1610–1616. doi:10.1002/cncr.21761

    Article  PubMed  Google Scholar 

  11. Singer S, Corson JM, Demetri GD et al (1995) Prognostic factors predictive of survival for truncal and retroperitoneal soft-tissue sarcoma. Ann Surg 221:185–195. doi:10.1097/00000658-199502000-00009

    Article  PubMed  CAS  Google Scholar 

  12. Stoeckle E, Coindre JM, Bonvalot S et al (2001) Prognostic factors in retroperitoneal sarcoma: a multivariate analysis of a series of 165 patients of the French Cancer Center Federation Sarcoma Group. Cancer 92:359–368. doi:10.1002/1097-0142(20010715)92:2<359::AID-CNCR1331>3.0.CO;2-Y

    Article  PubMed  CAS  Google Scholar 

  13. O’Brien MJ, Winawer SJ, Zauber AG et al (1990) The national polyp study: patient and polyp characteristics associated with high-grade dysplasia in colorectal adenomas. Gastroenterology 98:371

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Ipswich Hospital, Ipswich, IP4 5PD, UK

    Nikolaos Burbos

  2. Department of Obstetrics and Gynaecology, West Suffolk Hospital, Bury St’Edmunds, Suffolk, IP33 2QZ, UK

    Ilias Giarenis

  3. Department of Medical Oncology, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK

    Joe Ostrowski

  4. Department of Histopathology, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK

    Ray Lonsdale

  5. Department of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK

    Joaquin J. Nieto

  6. 60 Old Street, Haughley, Stowmarket, IP14 3NX, UK

    Nikolaos Burbos

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  1. Nikolaos Burbos
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  2. Ilias Giarenis
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  3. Joe Ostrowski
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  4. Ray Lonsdale
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  5. Joaquin J. Nieto
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Correspondence to Nikolaos Burbos.

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Burbos, N., Giarenis, I., Ostrowski, J. et al. Synchronous diagnosis of multiple tumours in a postmenopausal woman. Arch Gynecol Obstet 280, 627–630 (2009). https://doi.org/10.1007/s00404-009-0948-9

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  • DOI: https://doi.org/10.1007/s00404-009-0948-9

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