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Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios

Archives of Gynecology and Obstetrics volume 280, pages 549–552 (2009)Cite this article

Abstract

Purpose

To compare the placental pathologies and perinatal outcomes in fetal growth restriction (FGR) pregnancies with and without oligohydramnios.

Methods

A retrospective cohort study, comparing placental findings in all singleton deliveries with FGR.

Results

Macroscopic placental findings were available for 1,104 singleton FGR pregnancies. A total of 397 placentas were microscopically examined; of which 89 placentas were of FGR neonates who had oligohydramnios. No significant differences in placental vascular mal-perfusion were found between pregnancies with and without oligohydramnios (69.3 vs. 74.3%; P = 0.357). Likewise, no significant differences were noted between the groups regarding diffuse villous fibrosis (10.1 vs. 4.9%; P = 0.573), and amnion cell metaplasia (65.9 vs. 64.3%; P = 0.779). Cases of FGR complicated with oligohydramnios had significantly higher rates of perinatal mortality (9.9 vs. 5.9%; P = 0.028), preterm deliveries (34.9 ± 3.4 vs. 35.4 ± 3.1 weeks of pregnancy; P = 0.041), and lower birth weight (1,737 ± 542 vs. 1,845 ± 467 g; P = 0.002) compared to FGR without oligohydramnios.

Conclusions

Oligohydramnios is a significant risk factor for adverse perinatal outcome in FGR pregnancies; nevertheless, no significant differences in placental pathologies were noted.

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Conflict of interest statement

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Affiliations

  1. Department of Pathology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel

    Liat Apel-Sarid

  2. Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel

    Amalia Levy

  3. Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, P.O. Box 151, Beersheba, Israel

    Gershon Holcberg & Eyal Sheiner

Authors
  1. Liat Apel-Sarid
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  2. Amalia Levy
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  3. Gershon Holcberg
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  4. Eyal Sheiner
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Corresponding author

Correspondence to Eyal Sheiner.

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Apel-Sarid, L., Levy, A., Holcberg, G. et al. Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios. Arch Gynecol Obstet 280, 549–552 (2009). https://doi.org/10.1007/s00404-009-0937-z

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  • DOI: https://doi.org/10.1007/s00404-009-0937-z

Keywords

  • Fetal growth restriction
  • Placenta
  • Oligohydramnios
  • Vascular mal-perfusion